首页> 外文期刊>American Journal of Physiology >Vagal innervation modulates motor pattern but not initiation of canine gastric migrating motor complex.
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Vagal innervation modulates motor pattern but not initiation of canine gastric migrating motor complex.

机译:迷走神经支配可以调节运动模式,但不能调节犬胃迁移运动复合体。

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摘要

To determine the role of vagal nerves in initiation and modulation of the gastric migrating motor complex (MMC), motor activity was recorded in four dogs before and after total abdominal vagotomy during fasting, after exogenous intravenous motilin and insulin, and after feeding. After vagotomy, a temporally coordinated cyclic gastric and small bowel MMC persisted with an unchanged period. During gastric phase III, vagotomy decreased number of contractions (42 +/- 4 vs. 16 +/- 2), number of groupings of contractions (14 +/- 1 vs. 7 +/- 1), and motility index (12 +/- 1 vs. 10 +/- 1) and increased the duration between groupings (1 +/- 1 vs. 3 +/- 1 min) (P < 0.05 in each). Before and after vagotomy, motilin and insulin induced a premature MMC with minor changes in contractile pattern. A 200-g liver meal but not a 50-g liver meal inhibited the gastric MMC after vagotomy. A cyclic MMC persisted after vagotomy, but the contractile pattern during gastric phase III was altered. After a short recovery period, vagal innervation to the stomach modulates the pattern but not the presence of gastric interdigestive motility during phase III.
机译:为了确定迷走神经在胃迁移运动复合物(MMC)的启动和调节中的作用,在禁食期间,全腹静脉内胃动素和胰岛素注射后,以及进食后,在四只狗进行全腹迷走神经切除术前后,记录了其运动活动。迷走神经切断术后,时间协调的胃和小肠MMC持续存在,周期不变。在胃第三阶段,迷走神经切断术减少了收缩次数(42 +/- 4比16 +/- 2),收缩分组的数量(14 +/- 1比7 +/- 1)和运动指数(12 +/- 1对10 +/- 1),并增加了分组之间的持续时间(1 +/- 1对3 +/- 1分钟)(每个P <0.05)。在迷走神经切断术之前和之后,胃动蛋白和胰岛素诱导过早的MMC,收缩模式发生微小变化。迷走神经切断术后,200 g肝粉而不是50 g肝粉抑制胃MMC。迷走神经切断后仍存在周期性MMC,但胃III期的收缩模式发生了改变。在短暂的恢复期后,迷走神经对胃的调节会改变模式,但在第三阶段不会改变胃的消化道蠕动。

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