...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Current therapeutic research, clinical and experimental. >Effects of D-003, a Mixture of High-Molecular-Weight Sugar Cane Wax Acids, on Lipid Peroxidation Markers in Older Individuals: A Randomized, Double-Blind, Placebo-Controlled Study
【24h】

Effects of D-003, a Mixture of High-Molecular-Weight Sugar Cane Wax Acids, on Lipid Peroxidation Markers in Older Individuals: A Randomized, Double-Blind, Placebo-Controlled Study

机译：D-003，一种高分子量甘蔗蜡酸的混合物，对老年人脂质过氧化标记的影响：一项随机，双盲，安慰剂对照的研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: Aging is associated with increased lipid peroxidation (LP). D-003, a mixture of long-chain aliphatic primary acids purified from sugar cane wax, has been found to inhibit LP in experimental models and in healthy subjects.OBJECTIVES: The aim of this study was to assess the effects of D-003 on LP markers and the lipid profile of older individuals.METHODS: This randomized, double-blind, placebo-controlled study was conducted at the Plaza Veterans' House, Havana City, Cuba. Male and female patients aged >60 years with total cholesterol values of <6.1 mmol/L were eligible for inclusion in the study. After a 3-week lead-in and baseline assessment period, patients were randomized to receive PO D-003 5 mg/d, D-003 10 mg/d, or placebo for 8 weeks. The effect on copper-induced LP of low-density lipoprotein (LDL) particles was the primary variable, and the effects on plasma total antioxidant status (TAS), plasma malondialdehyde (MDA) concentration, plasma antioxidant enzyme (superoxide dismutase and gluta-thione peroxidase) activities, and the lipid profile were secondary variables. A clinical examination was performed at each visit (baseline, weeks 4 and 8). A clinical examination, LP, and blood tests (lipid profile, hematologic, and blood biochemistry safety indicators) were performed at baseline and after 8 weeks of treatment. Compliance and adverse events (AEs) were assessed at weeks 4 and 8. A 2-tailed P < 0.05 was considered statistically significant for comparisons of both continuous and categoric variables.
机译：背景：衰老与脂质过氧化（LP）增加有关。 D-003是从甘蔗蜡中纯化的长链脂肪族伯酸的混合物，在实验模型和健康受试者中均能抑制LP。目标：本研究的目的是评估D-003对糖尿病的影响LP标记和老年人的脂质分布。方法：这项随机，双盲，安慰剂对照的研究在古巴哈瓦那市的Plaza Veterans'House进行。年龄大于60岁且总胆固醇值小于6.1 mmol / L的男性和女性患者符合纳入研究的条件。经过3周的引导期和基线评估期后，患者被随机分配接受PO D-003 5 mg / d，D-003 10 mg / d或安慰剂治疗8周。低密度脂蛋白（LDL）颗粒对铜诱导的LP的影响是主要变量，对血浆总抗氧化剂状态（TAS），血浆丙二醛（MDA）浓度，血浆抗氧化剂酶（超氧化物歧化酶和戊二硫酮）的影响过氧化物酶活性和脂质分布是次要变量。每次访视时进行临床检查（基线，第4周和第8周）。在基线和治疗8周后进行了临床检查，LP和血液测试（血脂，血液学和血液生化安全指标）。在第4周和第8周评估依从性和不良事件（AE）。对于连续变量和分类变量的比较，2尾P <0.05被认为具有统计学意义。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号