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首页> 外文期刊>Current therapeutic research, clinical and experimental. >Hemodynamic Effects of an Intravenous Bolus of Epinephrine in Healthy Rats: A Randomized, Open-Label, Controlled Pilot Study
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Hemodynamic Effects of an Intravenous Bolus of Epinephrine in Healthy Rats: A Randomized, Open-Label, Controlled Pilot Study

机译：肾上腺素静脉输注对健康大鼠的血流动力学影响：一项随机，开放标签，对照的试验研究

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BACKGROUND: IV epinephrine is widely used in the treatment of shock to increase blood pressure (BP). However, whether it may also induce hypotension remains unknown.OBJECTIVE: The aim of this randomized, open-label, controlled pilot study was to observe hemodynamic changes after an IV bolus of epinephrine in healthy rats.METHODS: Healthy male Sprague-Dawley rats were randomized to 1 of 5 groups to receive IV epinephrine in doses of 0.5mug/kg (group 1); 1mug/kg (group 2); 2mug/kg (group 3); 4mug/kg (group 4); or 8 mug/kg (group 5). A sixth group received placebo (0.3 mL of normal saline) and served as the control. BP was monitored continuously. Mean arterial pressure (MAP) and heart rate (HR) were recorded at 0, 5, 15, and 30 seconds and 1, 2, 3, 4, 6, 8, 10, 12, 14, 16, 18, and 20 minutes after administration. The highest mean (SD) systolic BP (SBP) and the lowest mean (SD) diastolic BP (DBP) during this period were also recorded. Hypertension and hypotension were defined as BP increased or decreased >10% from baseline.
机译：背景：静脉注射肾上腺素广泛用于休克治疗以增加血压（BP）。然而，是否还会诱发低血压仍是未知的。目的：这项随机，开放标签，对照的先导研究的目的是观察健康大鼠静脉推注肾上腺素后的血流动力学变化。方法：健康雄性Sprague-Dawley大鼠随机分为5组中的1组接受0.5 ug / kg剂量的IV肾上腺素（第1组）; 1杯/公斤（第2组）; 2杯/公斤（第3组）; 4杯/千克（第4组）;或8杯/千克（第5组）。第六组接受安慰剂（0.3 mL生理盐水）并作为对照。连续监测血压。在0、5、15和30秒以及1、2、3、4、6、8、10、12、14、16、18和20分钟时记录平均动脉压（MAP）和心率（HR）管理后。还记录了此期间的最高平均（SD）收缩压（SBP）和最低平均（SD）舒张压（DBP）。高血压和低血压定义为BP从基线升高或降低> 10％。

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