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首页> 外文期刊>Current therapeutic research, clinical and experimental. >Effect of perinatal factors on time of first stool passage in preterm newborns: An open, prospective study
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Effect of perinatal factors on time of first stool passage in preterm newborns: An open, prospective study

机译：围产期因素对早产儿首次大便通过时间的影响：一项开放，前瞻性研究

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Background: Delayed passage of first stool by a newborn after birth might be an initial sign of clinical problems, such as meconium ileus, meconium plug syndrome, and intestinal atresia. Successful treatment of these conditions depends on early diagnosis, so it is imperative to note the time of first stool passage. Objective: The aim of this study was to assess the timing of first stool passage by preterm newborns in relation to antenatal exposure to magnesium sulfate (MgSO4) and a glucocorticoid (betamethasone) and to other perinatal factors, such as gestational age, respiratory distress syndrome (RDS), and time of first enteral feeding. Methods: The subjects in this prospective, open study were preterm newbornswho were born before 37 weeks' gestation and admitted to the neonatal intensive care units of Baskent University, Adana Teaching and Research Center, and Inonu University, Turgut Ozal Medical Center, between June 2003 and August 2004. Effects of antenatal exposure to MgSO4 and glucocorticoid onthe timing of first stool passage were assessed by comparing findings in exposed newborns to findings in an equal-sized group of gestational-age-matched subjects, derived from the study cohort, who were not exposed. Relationships between time of first stool passage and both gestational age and time of first enteral feeding were assessed. Results: Two hundred premature newborns (112 males, 88 females) were included in the study. The median age at the time of first stool passage was 16 hours, and 187 (93.5%) passed their first stool by 72 hours after birth. Delayed passage of first stool was noted in 33 (16.5%) newborns. One hundred sixty-eight (84.0%) newborns passed stool before enteral feeding was started. Gestational age and time to first enteral feeding were both significantly correlated with time of first stool passage (gestational age: r = -0.259, P < 0.001; first enteral feeding: r = 0.168, P = 0.017). Time of first stool passage was significantly later in 46 newborns with RDS than in 46 gestation al-age-matched newborns without RDS (mean [SD], 44.7 [39.7] vs 20.5 [18.4] hours, respectively; P < 0.05). The newborns whose mothers had received MgSO4 for tocolysis passed their first stool significantly later than gestational-age-matched controls (mean [SD], 26.5 [26.9] vs 11.3 [12.1] hours, respectively; P < 0.05). Antenatal exposure to betamethasone was not significantly correlated with timing of first stool passage. Conclusions: The results suggest that delayed passage of first stool in thesepreterm newborns was associated with gestational immaturity, delayed first enteral feeding, and RDS. Antenatal maternal exposure to MgSO4 was associated with later first stool passage in these preterm newborns, whereas antenatal exposure to betamethasone was not. 2006 Excerpta Medica, Inc.
机译：背景：新生儿出生后迟迟无法通过第一便便可能是临床问题的初步征兆，例如胎粪肠梗阻，胎粪栓塞综合征和肠道闭锁。这些疾病的成功治疗取决于早期诊断，因此必须注意首次大便通过的时间。目的：本研究的目的是评估早产儿初次排便的时间，与产前接触硫酸镁（MgSO4）和糖皮质激素（倍他米松）以及其他围产期因素（如胎龄，呼吸窘迫综合征）有关（RDS）和首次肠内喂养的时间。方法：这项前瞻性，开放性研究的对象是早孕婴儿，他们在妊娠37周之前出生，并于2003年6月之间入选了Baskent大学，Adana教学与研究中心和Inonu大学，Turgut Ozal医学中心的新生儿重症监护病房。 2004年8月和2004年8月。通过将暴露新生儿的发现与同等年龄组的胎龄匹配受试者的发现进行比较，评估了产前暴露于MgSO4和糖皮质激素对初次粪便通过的时间的影响。不暴露。评估了首次大便通过时间与胎龄和首次肠内喂养时间之间的关系。结果：本研究纳入了200例早产儿（男112例，女88例）。首次大便通过时的中位年龄为16小时，出生后72小时有187（93.5％）人通过首次大便。在33名（16.5％）新生儿中发现了第一次大便延迟通过。在开始肠内喂养之前，一百六十八（84.0％）的新生儿通过了大便。妊娠年龄和首次肠内喂养时间均与首次大便通过时间显着相关（胎龄：r = -0.259，P <0.001;首次肠内喂养：r = 0.168，P = 0.017）。 46例有RDS的新生儿的首次大便通过时间明显晚于46例无RDS的胎龄匹配新生儿（分别为[SD]，44.7 [39.7]和20.5 [18.4]小时; P <0.05）。母亲接受MgSO4进行宫缩溶解的新生儿的首次大便时间明显晚于与胎龄匹配的对照组（分别为[SD] 26.5 [26.9] vs 11.3 [12.1]小时; P <0.05）。产前暴露于倍他米松与第一次大便通过的时间没有显着相关。结论：结果提示这些早产儿初次排便延迟与妊娠不成熟，初次肠内进食延迟和RDS有关。在这些早产儿中，产前母体接触MgSO4与后来的第一次大便通行有关，而产前接触倍他米松则没有。 2006 Excerpta Medica，Inc.

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