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首页> 外文期刊>Allergy and asthma proceedings >The relationship between delta-forced vital capacity (percent fall in forced vital capacity at the PC20 dose of methacholine) and the maximal airway response in patients who have mild asthma.
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The relationship between delta-forced vital capacity (percent fall in forced vital capacity at the PC20 dose of methacholine) and the maximal airway response in patients who have mild asthma.

机译：轻度哮喘患者的德尔塔强制肺活量（在乙酰甲胆碱PC20剂量下强制肺活量下降的百分比）与最大气道反应之间的关系。

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摘要

Airway hypersensitivity is routinely evaluated by measuring the concentration (PC20) of inhaled methacholine or histamine that causes a 20% fall in forced expiratory volume in 1 second (FEV1). It has been suggested that a percentage fall in forced vital capacity (FVC) measured at the PC20 dose of inhaled agonist (deltaFVC) is a potentially useful clinical measure in patients who have asthma because it provides indirect information about gas trapping and therefore the maximal airway response. The relationships between serum eosinophil cationic protein (ECP) levels and the maximal airway response or deltaFVC are largely unknown. The aims of this study were to determine whether deltaFVC is correlated with the degree of maximal airway response and to examine the relationships between serum ECP and deltaFVC or maximal airway response in patients who have mild asthma. Fifty-eight patients with mild asthma underwent high-dose methacholine challenge testing. The PC20, maximal airway response, and deltaFVC were measured on the methacholine dose-response curves. Serum ECP levels also were determined. Subjects without a maximal response plateau (n = 33) had a significantly higher level of deltaFVC (17.9 +/- 4.1%) than subjects with a plateau (n = 25; 14.9 +/- 4.8%). A significant correlation was found between deltaFVC and the level of maximal response plateau (r = 0.446; p = 0.026). Not only methacholine PC20 but also maximal airway response or deltaFVC had no relationships with serum ECP levels. Our results suggest that deltaFVC can be used as a surrogate marker of maximal airway response in patients who have mild asthma and that neither maximal airway response nor deltaFVC reflects blood eosinophil activation any more than methacholine PC20.
机译：通常通过测量吸入的乙酰甲胆碱或组胺的浓度（PC20）来评估气道超敏性，该浓度在1秒钟内导致强迫呼气量下降20％（FEV1）。有人提出，在吸入性激动剂的PC20剂量下测得的强迫肺活量（FVC）百分率下降对哮喘患者是一种潜在有用的临床指标，因为它提供了有关气体捕集的间接信息，因此可提供最大的气道响应。血清嗜酸性粒细胞阳离子蛋白（ECP）水平与最大气道反应或deltaFVC之间的关系尚不清楚。本研究的目的是确定deltaFVC是否与最大气道反应程度相关，并检查轻度哮喘患者血清ECP和deltaFVC或最大气道反应之间的关系。 58例轻度哮喘患者接受了大剂量乙酰甲胆碱激发试验。在乙酰甲胆碱剂量反应曲线上测量PC20，最大气道反应和deltaFVC。还确定了血清ECP水平。没有最大反应平台的受试者（n = 33）比有平台的受试者（n = 25; 14.9 +/- 4.8％）的deltaFVC水平（17.9 +/- 4.1％）高得多。发现deltaFVC与最大响应平稳水平之间存在显着相关性（r = 0.446; p = 0.026）。不仅乙酰甲胆碱PC20而且最大的气道反应或deltaFVC与血清ECP水平也没有关系。我们的结果表明，deltaFVC可用作轻度哮喘患者最大气道反应的替代指标，并且最大气道反应和deltaFVC都不能比乙酰甲胆碱PC20更能反映血液嗜酸性粒细胞的激活。

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