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首页> 外文期刊>Aging cell. >Optimal body weight for health and longevity: bridging basic, clinical, and population research
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Optimal body weight for health and longevity: bridging basic, clinical, and population research

机译：最佳体重，健康长寿：将基础，临床和人群研究相结合

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Excess body weight and adiposity cause insulin resistance, inflammation, and numerous other alterations in metabolic and hormonal factors that promote atherosclerosis, tumorigenesis, neurodegeneration, and aging. Studies in both animals and humans have demonstrated a beneficial role of dietary restriction and leanness in promoting health and longevity. Epidemiological studies have found strong direct associations between increasing body mass index (BMI) and risks of developing type 2 diabetes, cardiovascular disease, and several types of cancer, beginning from BMI of 20-21kg m-2. Although a recent meta-analysis suggests that overweight individuals have significantly lower overall mortality than normal-weight individuals, these data are likely to be an artifact produced by serious methodological problems, especially confounding by smoking, reverse causation due to existing chronic disease, and nonspecific loss of lean mass and function in the frail elderly. From a clinical and public health point of view, maintaining a healthy weight through diet and physical activity should remain the cornerstone in the prevention of chronic diseases and the promotion of healthy aging.
机译：体重过重和肥胖会导致胰岛素抵抗，炎症以及代谢和激素因素的许多其他变化，从而导致动脉粥样硬化，肿瘤发生，神经变性和衰老。对动物和人类的研究表明，饮食限制和瘦肉对促进健康和长寿具有有益的作用。流行病学研究发现，体重指数（BMI）从20-21kg m-2开始，在增加的体重指数（BMI）与罹患2型糖尿病，心血管疾病和几种癌症的风险之间有着密切的直接联系。尽管最近的一项荟萃​​分析表明，超重个体的总死亡率明显低于正常体重个体，但这些数据可能是由严重的方法学问题（尤其是与吸烟混淆，由于现有慢性疾病引起的反向因果关系和非特异性）产生的人工产物体弱的老年人失去瘦肉和功能。从临床和公共卫生的角度来看，通过饮食和体育锻炼来保持健康的体重应该仍然是预防慢性病和促进健康衰老的基石。

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