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首页> 外文期刊>Current therapeutic research, clinical and experimental. >Effect of Thymoquinone on Oxidative Stress in Escherichia coli-Induced Pyelonephritis in Rats
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Effect of Thymoquinone on Oxidative Stress in Escherichia coli-Induced Pyelonephritis in Rats

机译：胸腺醌对大肠埃希菌致肾盂肾炎大鼠氧化应激的影响

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BACKGROUND: Recurrent urinary tract infections are important in children and adults with diabetes mellitus and/or incontinence due to risk of pyelonephritis (PYN) and renal damage. There is a positive correlation released free radicals during PYN and renal damage. Experimental studies showed that antioxidant agents improve renal damage when used immediately after bacterial inoculation.Objective: The aim of the present study was to evaluate whether treatment by thymoquinone (TQ) before or during Escherichia coli inoculation prevents oxidative damage in acute pyelonephritis (PYN) in an ascending obstructive rat model.METHODS: In this study, 42 Wistar rats were grouped as follows: control, PYN (24, 48, and 72 hours), and TQ-PYN (24, 48, and 72 hours). E. coli (1 X109 colony forming units) was inoculated into the bladder via urethral catheterization in both the PYN and TQ groups. TQ injections were performed 24 hours before bacteria inoculation and repeated at 24-hour intervals during the indicated time at a dose of 10 mg/kg body weight intraperitoneally in TQ groups.RESUUTS: Superoxide dismutase activity was statistically lower in the TQ-PYN-48 and -72 groups than the PYN-48 and -72 groups (P < 0.001, P = 0.004, respectively). Catalase activity was significantly higher in PYN-24, -48, and -72 groups than the control group (P < 0.001). In addition, there was a significant difference between the TQ-PYN-24, -48, and -72 groups and PYN groups in terms of glutathione peroxidase activity (P < 0.001, P = 0.026, P = 0.046, respectively). When the TQ-PYN-72 group was compared with the PYN-72 group, malondial-dehyde levels were significantly lower in the TQ-PYN-72 group than in the PYN-72 group (P = 0.033)- A histologic examination also confirmed the protective effect of TQ. In statistical analysis of histopathologic findings, there were significant differences between the PYN-24 and TQ-PYN-24, PYN-48 and TQ-PYN-48, and PYN-72 and TQ-PYN-72 groups (P = 0.008, P < 0.001, P < 0...
机译：背景：由于患有肾盂肾炎（PYN）和肾损害的风险，尿路反复感染在患有糖尿病和/或失禁的儿童和成人中很重要。 PYN和肾损伤期间释放的自由基呈正相关。实验研究表明，在细菌接种后立即使用抗氧化剂可以改善肾脏损害。目的：本研究的目的是评估在大肠杆菌接种之前或期间通过胸腺醌（TQ）进行的治疗是否可以预防急性肾盂肾炎（PYN）中的氧化损伤。方法：在这项研究中，将42只Wistar大鼠分为以下两组：对照组，PYN（24、48和72小时）和TQ-PYN（24、48和72小时）。在PYN和TQ组中，都通过尿道导管插入大肠杆菌（1 X109个菌落形成单位）。 TQ组在细菌接种前24小时进行TQ注射，并在指定的时间间隔内以24 mg的时间间隔以10 mg / kg体重的剂量在TQ组进行腹膜内注射.TQ-PYN-48的超氧化物歧化酶活性在统计学上较低-72和-72组比PYN-48和-72组（分别为P <0.001，P = 0.004）。 PYN-24，-48和-72组的过氧化氢酶活性显着高于对照组（P <0.001）。另外，就谷胱甘肽过氧化物酶活性而言，TQ-PYN-24，-48和-72组与-PYN组之间存在显着差异（分别为P <0.001，P = 0.026，P = 0.046）。当将TQ-PYN-72组与PYN-72组进行比较时，TQ-PYN-72组的丙二醛水平显着低于PYN-72组（P = 0.033）-组织学检查也证实了TQ的保护作用。在组织病理学结果的统计分析中，PYN-24和TQ-PYN-24，PYN-48和TQ-PYN-48以及PYN-72和TQ-PYN-72组之间存在显着差异（P = 0.008，P <0.001，P <0 ...

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