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Effect of Intraoperative Paracetamol on Catheter-Related Bladder Discomfort: A Prospective, Randomized, Double-Blind Study

机译：术中扑热息痛对导管相关膀胱不适的影响：一项前瞻性，随机，双盲研究

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The insertion of urinary catheters during urinary surgical interventions may lead to catheter-related bladder discomfort (CRBD) in the postoperative period. We aimed to evaluate the effect of single-dose intravenous paracetamol on CRBD. In this randomized, controlled, double-blind study, 64 patients (age >18 years, American Society of Anesthesiologists Physical Status I-II) requiring urinary bladder catheterization for percutaneous nephrolithotomy were assigned to groups that received either intravenous paracetamol (15 mg/kg) (group P) or NaCl 0.9% solution (control group [group C]) 30 minutes before the end of surgery. Patients received patient-controlled analgesia (10-mg bolus of meperidine, without infusion, 20-minute lock out) postoperatively. CRBD and pain status were assessed at 30 minutes and 1, 2, 4, 6, and 12 hours postoperatively. Postoperative meperidine requirement and patient and surgeon satisfaction were assessed.Group P had significantly lower CRBD scores at all time points except at 12 hours postoperatively compared with group C (P < 0.05). Total meperidine consumption was significantly higher in group C (P < 0.05). Patient and surgeon satisfaction scores were significantly higher in group P (P < 0.05). Intraoperative single-dose paracetamol was found to be effective in reducing the severity of CRBD and pain in urologic surgery. We suggest that it may be an efficient, reliable, easy-to-apply drug for CRBD. ClinicalTrials.gov identifier: NCT01652183.
机译：泌尿外科手术期间插入导尿管可能会导致术后导管相关性膀胱不适（CRBD）。我们旨在评估单剂量静脉对乙酰氨基酚对CRBD的影响。在这项随机，对照，双盲研究中，将64例需要经皮肾镜取石术而需要膀胱导管置入术的患者（年龄> 18岁，美国麻醉医师协会身体状况I-II）分配到接受静脉对乙酰氨基酚（15 mg / kg）治疗的组中。 ）（P组）或NaCl 0.9％溶液（对照组[C组]）在手术结束前30分钟。术后患者接受患者自控镇痛（10 mg哌替啶大剂量，不输注，停药20分钟）。术后30分钟，1、2、4、6和12小时评估CRBD和疼痛状态。评估术后的哌替啶需求量以及患者和手术医生的满意度。除C组术后12小时外，P组在所有时间点的CRBD评分均明显低于C组（P <0.05）。 C组的总哌啶消耗量显着更高（P <0.05）。 P组患者和外科医生的满意度得分显着更高（P <0.05）。发现术中单剂量对乙酰氨基酚可有效降低CRBD的严重程度和泌尿外科手术中的疼痛。我们建议它可能是一种有效，可靠，易于应用的CRBD药物。 ClinicalTrials.gov标识符：NCT01652183。

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