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首页> 外文期刊>Current therapeutic research, clinical and experimental. >Ruptured Hepatic Carcinoma After Transcatheter Arterial Chemoembolization
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Ruptured Hepatic Carcinoma After Transcatheter Arterial Chemoembolization

机译：经导管动脉化疗栓塞后破裂的肝癌

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Background: Transcatheter arterial chemoembolization (TACE) is recommended as the first-line therapy for unresectable hepatic carcinoma (HCC). Serious complications such as hepatic abscess and hepatic decompensation are well known, but rupture of HCC after TACE is a rare complication. Objective: The aim of this study was to identify the associated risk factors and the outcomes resulting from ruptured HCC after TACE.Methods: A retrospective analysis was performed in 6 patients who experienced ruptured HCC after TACE.Results: All patients underwent chemoembolization after superselective catheterization of the appropriate hepatic artery. The interval between the treatment of TACE and ruptured HCC was 6 to 17 days (mean [SD] 10.33 [4.08] days). Common features in ruptured HCC were large tumor size, location of the tumor adjacent to liver capsular membrane, and complete occlusion of the tumor feeding artery, especially in those with a large amount of iodized oil plus polyvinyl alcohol particles. Two patients underwent emergency embolization, and 4 patients received conservative treatment. Except for 2 patients treated conservatively who died 45 and 68 days after ruptured HCC with hepatic decompensation, the other 4 patients survived to the 6-month follow-up.Conclusions: Ruptured HCC after TACE is a rare but serious complication. Large tumor size, location of the tumor adjacent to the liver capsule, and complete occlusion of the feeding artery may be predisposing factors. More research is needed to examine which patients presenting with ruptured HCC after TACE would benefit from conservative or emergency arterial embolization procedures.
机译：背景：经导管动脉化疗栓塞（TACE）被推荐作为不可切除肝癌（HCC）的一线治疗方法。严重的并发症如肝脓肿和肝代偿失调是众所周知的，但是TACE后HCC破裂是一种罕见的并发症。目的：本研究旨在确定TACE后HCC破裂的相关危险因素和结果。方法：对6例TACE后HCC破裂的患者进行回顾性分析。结果：所有患者均在超选择性导管插入后接受了化学栓塞术适当的肝动脉。 TACE治疗与肝癌破裂之间的间隔为6到17天（平均[SD] 10.33 [4.08]天）。肝癌破裂的常见特征是大的肿瘤大小，邻近肝囊膜的肿瘤位置以及肿瘤的供血动脉完全闭塞，特别是在那些加碘油加聚乙烯醇颗粒的情况下。 2例患者接受了紧急栓塞，4例患者接受了保守治疗。除了2例经保守治疗的患者因肝代偿失调而在肝癌破裂后45和68天死亡，其余4例患者存活至6个月的随访。结论：TACE后破裂的肝癌是一种罕见但严重的并发症。较大的肿瘤大小，邻近肝囊的肿瘤位置以及进食动脉完全闭塞可能是诱发因素。需要更多的研究来检查哪些患者在TACE后表现为HCC破裂的患者将从保守或紧急动脉栓塞手术中受益。

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