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首页> 外文期刊>Current therapeutic research, clinical and experimental. >Comparison of Propofol and Ketamine-Propofol Mixture (Ketofol) on Laryngeal Tube-Suction II Conditions and Hemodynamics: A Randomized, Prospective, Double-Blind Trial
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Comparison of Propofol and Ketamine-Propofol Mixture (Ketofol) on Laryngeal Tube-Suction II Conditions and Hemodynamics: A Randomized, Prospective, Double-Blind Trial

机译：丙泊酚和氯胺酮-丙泊酚混合物（Ketofol）在喉管抽吸II条件和血液动力学方面的比较：一项随机，前瞻性，双盲试验

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Objective: The aim of our study is to compare the effect of ketamine-propofol mixture (ketofol) and propofol on the laryngeal tube-Suction 11 (LTS II) insertion conditions and hemodynamics. Methods: Eighty American Society of Anesthesiologists class 1 and 2 patients were divided into 2 random groups to receive either 1 |ig/kg remifentanil and propofol 2 mg/kg in Group P (n = 40), or 1 ug/kg remifentanil and ketofol (using a 1:1 single syringe mixture of 5 mg/mL ketamine and 5 mg/mL propofol) in Group K (n = 40) before induction of anesthesia. After induction, LTS II was inserted. Heart rate and noninvasive blood pressure were recorded before induction of anesthesia (t0); immediately following induction (t,); immediately after LTS II insertion (t2); and 3 minutes (t3), 5 minutes (t4), and 10 (t5) minutes after LTS II insertion. Conditions of insertion of LTS II were assessed and scored 1 to 3 using 6 variables as follows: mouth opening, swallowing, coughing, head and body movements, laryngospasm, and ease of LTS II insertion by the same experienced anesthesiologist who did not know the agents. LTS II insertion summed score was prepared depending upon these variables.Results: In regard to LTS II insertion summed score. Group K was more favorable than Group P (P < 0.05). Apnea duration was longer in Group P (385.0 seconds [range = 195.0-840.0 seconds]) compared with Group K (325.50 seconds [range = 60.0-840.0 seconds]) but this was not statically significant. The heart rate values were significantly lower at all measurement intervals in both groups compared with the baseline values (P < 0.05). There was no difference in heart rate between Group P and Group K. The mean arterial pressure values were significantly lower at all measurement intervals in Group P compared with baseline values (P < 0.05). In Group K, the mean arterial pressure values were significantly lower at all measurement intervals compared with the baseline values, except t^ (P < 0.05). There was a significant difference between Group P and Group K in terms of mean arterial pressure at t3 (P < 0.05). Conclusions: We found that ketofol provided better insertion summed score for LTS II than propofol, with minimal hemodynamic changes.
机译：目的：我们的研究目的是比较氯胺酮-丙泊酚混合物（ketofol）和丙泊酚对喉管抽吸11（LTS II）插入条件和血液动力学的影响。方法：将八十个美国麻醉医师学会的1级和2级患者分为2个随机组，分别在P组（n = 40）中接受1 ig / kg瑞芬太尼和丙泊酚2 mg / kg，或1 ug / kg瑞芬太尼和ketofol麻醉前，在K组（n = 40）中（使用5 mg / mL氯胺酮和5 mg / mL异丙酚的1：1单针注射器混合物）。诱导后，插入LTS II。麻醉诱导前记录心率和无创血压（t0）;归纳后立即（t，）; LTS II插入后立即（t2）; LTS II插入后3分钟（t3），5分钟（t4）和10（t5）分钟。 LTS II的插入条件通过以下六个变量评估和评分为1-3，分别为：张口，吞咽，咳嗽，头部和身体运动，喉痉挛以及同一名不知其病因的经验丰富的麻醉师是否容易插入LTS II 。根据这些变量准备LTS II插入总分。结果：关于LTS II插入总分。 K组优于P组（P <0.05）。与K组（325.50秒[范围= 60.0-840.0秒]）相比，P组（385.0秒[范围= 195.0-840.0秒]）的呼吸暂停持续时间更长，但这并不是静态的。与基线值相比，两组的所有测量间隔的心率值均显着降低（P <0.05）。 P组和K组之间的心率无差异。与基线值相比，P组在所有测量间隔的平均动脉压值均显着降低（P <0.05）。在K组中，除t ^外，所有测量间隔的平均动脉压值均显着低于基线值（P <0.05）。 P组和K组之间在t3时的平均动脉压方面存在显着差异（P <0.05）。结论：我们发现，ketofol提供的LTS II插入总得分比丙泊酚更好，血液动力学变化最小。

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