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首页> 外文期刊>Current therapeutic research, clinical and experimental. >The Use of Platelet-Rich Fibrin in Combination With Biphasic Calcium Phosphate in the Treatment of Bone Defects: A Histologic and Histomorphometric Study
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The Use of Platelet-Rich Fibrin in Combination With Biphasic Calcium Phosphate in the Treatment of Bone Defects: A Histologic and Histomorphometric Study

机译：富含血小板的纤维蛋白与双相磷酸钙结合在骨缺损治疗中的应用：组织学和组织形态学研究

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Background: Platelet-rich fibrin (PRF) is a leukocyte and platelet concentrate containing many growth factors. Its potential for hard tissue augmentation as a sole grafting material or in combination with other grafting materials has been investigated in many studies. Objective: The aim of this histologic study was to evaluate the efficacy of PRF mixed with biphasic calcium phosphate (BCP) on bone regeneration in surgically created bone defects. Methods: Defects 5 mm in diameter were created in both tibias of 6 sheep. The defects were left empty or grafted with BCP, PRF, or BCP + PRF. Animals were killed at 10, 20, and 40 days. The specimens underwent histologic and histomorphometric analysis. Results: None of the groups displayed any signs of necrosis. Inflammation was observed in all groups at 10 days; 2 specimens of PRF + BCP and all empty defects showed inflammatory cell infiltration at 20 days. During the 40-day evaluation period, the PRF + BCP group showed the highest ratios of new bone. The other 3 groups showed statistically similar results. In the BCP and PRF +- BCP groups, the residual graft ratios were decreased at consecutive time intervals. The difference between the 2 groups was not statistically significant during follow-up. Conclusions: The current study revealed a histomorphometric increase in bone formation with the addition of PRF to BCP in surgically created defects in sheep tibia.
机译：背景：富含血小板的纤维蛋白（PRF）是一种含有许多生长因子的白细胞和血小板浓缩液。在许多研究中已经研究了其作为单独的移植材料或与其他移植材料结合使用的硬组织增强的潜力。目的：本组织学研究的目的是评估PRF与双相磷酸钙（BCP）混合对手术造成的骨缺损的骨再生的有效性。方法：在6只绵羊的两个胫骨上均形成直径为5 mm的缺陷。将缺损留空或移植BCP，PRF或BCP + PRF。在第10、20和40天处死动物。对标本进行组织学和组织形态学分析。结果：所有组均未显示任何坏死迹象。在第10天，所有组均观察到炎症; 2天的PRF + BCP标本和所有空缺均在20天时出现炎性细胞浸润。在40天的评估期内，PRF + BCP组的新骨比例最高。其他3组显示出统计学上相似的结果。在BCP和PRF +-BCP组中，残余接枝率在连续的时间间隔内降低。随访期间两组之间的差异无统计学意义。结论：目前的研究揭示了在山羊胫骨手术造成的缺损中，在BCP中添加PRF后，骨形态的形态计量学增加。

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