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首页> 外文期刊>Current therapeutic research, clinical and experimental. >The Effect of Trapidil and Bevacizumab on Tracheal Anastomotic Wound Healing
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The Effect of Trapidil and Bevacizumab on Tracheal Anastomotic Wound Healing

机译：曲哌地尔和贝伐单抗对气管吻合口伤口愈合的影响

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Background: Although bevacizumab has deleterious effects on the healing of colonic anastomoses, trapidil improves wound healing of colonic and tracheal anastomoses. Objective: We aimed to assess the effects of bevacizumab and Uapidil on wound healing after tracheal transection.Materials and methods: We evaluated 35 rats divided in 5 groups: bevacizumab (Group I. n = 7), trapidil (Group II, n = 7), trapidil + bevacizumab (Group III, n = 7), controls (Group IV, n = 7), and sham (Group V, n = 7). Anastomotic healing was assessed by measurement of bursting pressure and inflammation score at the anastomotic region on the seventh day. Results: The bursting pressures of Group II, Group III, and Group V were significantly higher than controls (P = 0.001, P = 0.033, and P = 0.035, respectively). Fibrosis was significantly high in the sham group when compared with the other four groups (P = 0.047). Conclusions: Although bevacizumab seems to impair anastomotic healing, trapidil can be suggested to improve tracheal anastomoses.
机译：背景：尽管贝伐单抗对结肠吻合口的愈合具有有害作用，但曲非尼可改善结肠和气管吻合口的伤口愈合。目的：评估贝伐单抗和Uapidil对气管横切后伤口愈合的影响。材料与方法：我们评估了35只大鼠，分为5组：贝伐单抗（I组，n = 7），曲霉定（II组，n = 7） ），特拉替尼+贝伐单抗（III组，n = 7），对照组（IV组，n = 7）和假（V组，n = 7）。通过在第七天测量吻合口处的破裂压力和炎症评分来评估吻合口愈合。结果：II组，III组和V组的破裂压力显着高于对照组（分别为P = 0.001，P = 0.033和P = 0.035）。与其他四组相比，假手术组的纤维化明显较高（P = 0.047）。结论：尽管贝伐单抗似乎会损害吻合口愈合，但仍可建议使用曲吡地改善气管吻合口。

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