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首页> 外文期刊>Aging cell. >Temperature affects longevity and age-related locomotor and cognitive decay in the short-lived fish Nothobranchius furzeri.
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Temperature affects longevity and age-related locomotor and cognitive decay in the short-lived fish Nothobranchius furzeri.

机译：温度会影响寿命短的鱼类Nothobranchius furzeri的寿命和与年龄有关的运动能力和认知能力衰退。

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Temperature variations are known to modulate aging and life-history traits in poikilotherms as different as worms, flies and fish. In invertebrates, temperature affects lifespan by modulating the slope of age-dependent acceleration in death rate, which is thought to reflect the rate of age-related damage accumulation. Here, we studied the effects of temperature on aging kinetics, aging-related behavioural deficits, and age-associated histological markers of senescence in the short-lived fish Nothobranchius furzeri. This species shows a maximum captive lifespan of only 3 months, which is tied with acceleration in growth and expression of aging biomarkers. These biological peculiarities make it a very convenient animal model for testing the effects of experimental manipulations on life-history traits in vertebrates. Here, we show that (i) lowering temperature from 25 degrees C to 22 degrees C increases both median and maximum lifespan; (ii) life extension is due to reduction in the slope of the age-dependent acceleration in death rate; (iii) lowering temperature from 25 degrees C to 22 degrees C retards the onset of age-related locomotor and learning deficits; and (iv) lowering temperature from 25 degrees C to 22 degrees C reduces the accumulation of the age-related marker lipofuscin. We conclude that lowering water temperature is a simple experimental manipulation which retards the rate of age-related damage accumulation in this short-lived species.
机译：已知温度变化会调节poikilotherm中的衰老和生活史特征，与蠕虫，苍蝇和鱼类不同。在无脊椎动物中，温度通过调节与年龄相关的死亡率加速斜率来影响寿命，这被认为反映了与年龄相关的伤害累积率。在这里，我们研究了温度对短命鱼类Nothobranchius furzeri衰老动力学，衰老相关行为缺陷和衰老的年龄相关组织学标志的影响。该物种的最大圈养寿命只有3个月，这与加速生长和老化生物标志物的表达有关。这些生物学特性使其成为测试实验操作对脊椎动物生活史特征的影响的非常方便的动物模型。在这里，我们表明（i）将温度从25摄氏度降低到22摄氏度会增加中值寿命和最大寿命; （ii）延长寿命是由于与年龄有关的死亡率下降的斜率减小; （iii）将温度从25摄氏度降低到22摄氏度可延缓与年龄有关的运动和学习障碍的发作; （iv）将温度从25摄氏度降低到22摄氏度，减少了与年龄有关的标志物脂褐素的积累。我们得出的结论是，降低水温是一种简单的实验操作，可延缓这种短命物种中与年龄相关的伤害积累的速率。

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