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首页> 外文期刊>Current therapeutic research, clinical and experimental. >Effect of Benincasa hispida Fruits on Testosterone-Induced Prostatic Hypertrophy in Albino Rats
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Effect of Benincasa hispida Fruits on Testosterone-Induced Prostatic Hypertrophy in Albino Rats

机译：Benincasa hispida水果对白化大鼠睾丸激素诱导的前列腺肥大的影响

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BACKGROUND: Benincasa hispida Cogn. has been used traditionally in India for the management of urinary disorders. The fruit of B hispida is used as a diuretic and the seeds have been reported to possess antiangiogenic effects in prostate cells. OBJECTIVE: The aim of the present study was to examine the effect of petroleum ether extract, ethanolic extract, and B hispida seed oil on hyperplasia of the prostate induced by the subcutaneous administration of testosterone in rats. METHODS: In vitro studies were performed to determine the 5alpha-reductase inhibitory potential of the extracts. The results of those studies paved the way for the pharmacologic screening of the extracts to assess their potential against testosterone-induced hyperplasia in rats. Nine groups containing 10 rats per group were created for this study. Hyperplasia was induced by administration of testosterone (3 mg/kg SC) for 14 days in all the groups except the vehicle-treated group. Simultaneous administration of petroleum ether extract (100 or 200 mg/kg PO), ethanolic extract (100 or 200 mg/kg PO), and B hispida seed oil (20 or 40 mg/kg PO) was conducted. A standard 5(X-reductase inhibitor (ie, finasteride) was used as a positive control. The weight of the rats was recorded on day 0 (ie, day 1 of the study) and on day 14, and the influence of testosterone and test extracts on the weight of the rats was determined. On day 14, rats were euthanized; prostates were dissected out, and weighed. The rats' prostate/body weight (P/BW) ratio was then determined. Histologic examinations were performed on prostates from each group. RESULTS: The petroleum ether extract as well as B hispida seed oil exhibited inhibition of 5a-reductase activity in in vitro studies. Ethanolic extract did not exhibit significant inhibitory potential in vitro. Further in vivo study found that testosterone treatment significantly increased the rats' P/BW ratio in all the groups except the vehicle-treated rats, and this increase ...
机译：背景：Benincasa hispida Cogn。在印度，传统上已使用它来治疗泌尿系统疾病。 B Hispida的果实被用作利尿剂，据报道该种子在前列腺细胞中具有抗血管生成作用。目的：本研究旨在探讨石油醚提取物，乙醇提取物和棉球菌种子油对大鼠皮下注射睾丸激素所致前列腺增生的影响。方法：进行了体外研究以确定提取物的5α-还原酶抑制潜力。这些研究的结果为提取物的药理筛选铺平了道路，以评估其对大鼠睾丸激素诱导的增生的潜力。为该研究创建了每组10只大鼠的9个组。除赋形剂治疗组外，所有组均通过给予睾丸激素（3 mg / kg SC）14天来诱发增生。同时施用石油醚提取物（100或200 mg / kg PO），乙醇提取物（100或200 mg / kg PO）和双歧杆菌种子油（20或40 mg / kg PO）。使用标准5（X-还原酶抑制剂（即非那雄胺））作为阳性对照，在第0天（即研究的第1天）和第14天记录大鼠的体重，以及睾丸激素和确定大鼠体重的测试提取物，在第14天，对大鼠实施安乐死;解剖前列腺并称重，然后确定大鼠的前列腺/体重（P / BW）比;对前列腺进行组织学检查结果：在体外研究中，石油醚提取物和B Hispida种子油均表现出对5a-还原酶活性的抑制作用;乙醇提取物在体外未显示出明显的抑制潜力;进一步的体内研究发现，睾丸激素治疗显着增加除用赋形剂处理的大鼠外，所有组的大鼠的P / BW比都增加了。

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