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Effects of a Topical Hemostatic Agent on an Epistaxis Model in Rabbits

机译：局部止血剂对家兔模型的影响

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BACKGROUND: Ankaferd BloodStopper (ABS) is a standardized herbal compound consisting of 5 different plant extracts. ABS, as a topical medicinal product, has been approved by the Turkish Ministry of Health for the management of dermal, external postsurgical and postdental surgery bleedings.OBJECTIVE: The aim of this study was to assess the hemostatic effect of ABS in an experimental epistaxis model.METHODS: Adult female New Zealand rabbits were used in this study. Standardized full-thickness mucosal wounds were created to provide bleeding on the right and left side of the nasal septum of rabbits with a 3-mm surgical punch. To stop bleeding, the wounds were treated with topical ABS on one side and with topical isotonic saline solution as a control on the other side of the nasal septum. Investigators were blinded to treatment. The duration of bleeding was measured in order to compare the hemostatic effect with ABS or topical isotonic saline solution. The wounds were observed for the duration of bleeding in order to compare the hemostatic effect of ABS with isotonic saline solution and acute adverse effects (AEs) for 30 minutes by a researcher blinded to treatment groups.RESULTS: Six rabbits (mean weight, 2.6 kg [range, 2.3-3.1 kg}) were used in this study. Mean (SD) bleeding time in the wounds administered ABS (98 [17} sec) was significantly less than that of the controls (266 [36} sec; P = 0.004). No AEs were observed up to 30 minutes after study initiation.CONCLUSION: This study suggests that ABS may be more effective in reducing time to hemostasis when compared with isotonic saline solution in this epistaxis model in rabbits.
机译：背景：Ankaferd BloodStopper（ABS）是由5种不同植物提取物组成的标准化草药化合物。 ABS是一种局部用药，已获得土耳其卫生部的批准，可用于治疗皮肤，外部手术后和牙后手术出血。方法：本研究使用成年雌性新西兰兔。创建标准化的全层粘膜伤口，以3毫米的手术冲头在兔子的鼻中隔左右两侧提供出血。为了止血，在鼻中隔的一侧用局部ABS和局部等渗盐溶液作为对照治疗伤口。调查人员不愿接受治疗。测量出血的持续时间，以便与ABS或局部等渗盐溶液比较止血效果。观察伤口的出血持续时间，以比较对治疗组不知情的研究人员对等渗盐溶液的ABS止血效果和急性不良反应（AEs）进行30分钟的结果。结果：六只兔子（平均体重2.6 kg） [范围2.3-3.1 kg}）用于本研究。使用ABS伤口的平均（SD）出血时间（98 [17} sec）明显少于对照组（266 [36} sec; P = 0.004）。在研究开始后的30分钟内未观察到AE。结论：这项研究表明，在等渗模型中，与等渗盐溶液相比，ABS可以更有效地减少止血时间。

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