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首页> 外文期刊>Current therapeutic research, clinical and experimental. >In Vitro Antifungal Activity of Ankaferd Blood Stopper Against Candida albicans
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In Vitro Antifungal Activity of Ankaferd Blood Stopper Against Candida albicans

机译：Ankaferd止血剂对白色念珠菌的体外抗真菌活性

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BACKGROUND: Candida albicans is a memeber of the oral flora that can lead to various complications in immunosupresive patients after oral surgery processes. Ankaferd Blood Stopper~R (ABS) is a medical plant extract that is safe to use in patients with dental surgery bleedings in Turkey.OBJECTIVE: The study evaluated the antifungal activity of ABS medicinal plant extract against C albicans using the agar diffusion and broth microdilution methods.METHODS: The plant extract antifungal activity was assessed in vitro either by applying the ABS extract directly and by applying different concentrations of ABS onto Candida culture. For these experiments an agar diffusion method was used. To determine the minimum inhibitory concentration (MIC), a broth microdilution method was used.RESULTS: Different volumes of the active substance (10, 20, 30, and 40 muL) were applied onto Candida (0.5 McFarland solution) cultivated plate; Candida growth was inhibited in accordance with the volumes of ABS. However, when various dilutions of ABS (1:2, 1:20, 1:40, and 1:80) were added as drops containing 20 muL, no antifungal effects were found. No MIC values were identified using broth microdilution. When different dilutions of ABS containing 100muL of 0.5 McFarland solution of C albicans were cultured depending on the time (10, 20, 30, and 40 minutes), the effect of the duration was not significant.CONCLUSION: The various tests were carried out to investigate antifungal effects of ABS on Candida, but none were found.
机译：背景：白色念珠菌是口腔菌群的成员，在口腔外科手术后免疫抑制患者中可能导致各种并发症。目的：Akaferd Blood Stopper〜R（ABS）是一种药用植物提取物，可安全用于土耳其牙科手术出血的患者。目的：该研究使用琼脂扩散和肉汤微稀释技术评估了ABS药用植物提取物对白色念珠菌的抗真菌活性。方法：方法：通过直接应用ABS提取物或将不同浓度的ABS应用于念珠菌培养物来评估植物提取物的抗真菌活性。对于这些实验，使用琼脂扩散方法。结果：将不同体积的活性物质（10、20、30和40μL）分别施加到念珠菌（0.5 McFarland溶液）培养板上;测定最低抑菌浓度（MIC）。根据ABS的量，念珠菌的生长受到抑制。但是，当添加各种稀释的ABS稀释液（1：2、1：20、1：40和1:80）作为含有20μL的液滴时，未发现抗真菌作用。使用肉汤微量稀释未鉴定到MIC值。当根据时间（10、20、30和40分钟）培养含有100μl0.5 McFarland白色念珠菌溶液的ABS不同稀释度时，持续时间的影响并不显着。结论：研究了ABS对念珠菌的抗真菌作用，但未发现。

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