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首页> 外文期刊>Current therapeutic research, clinical and experimental. >Effects of 2 Different Doses of Pregabalin on Morphine Consumption and Pain After Abdominal Hysterectomy: A Randomized, Double-Blind Clinical Trial
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Effects of 2 Different Doses of Pregabalin on Morphine Consumption and Pain After Abdominal Hysterectomy: A Randomized, Double-Blind Clinical Trial

机译：2种不同剂量的普瑞巴林对子宫全子宫切除术后吗啡消耗和疼痛的影响：一项随机双盲临床试验

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BACKGROUND: Pregabalin has a similar pharmacologic profile to that of its developmental predecessor gabapentin but has shown greater analgesic activity in rodent models of neuropathic pain.OBJECTIVE: The objective of the study was to compare the effects of 2 different doses of pregabalin and placebo on postoperative pain and morphine consumption.METHODS: Ninety patients who underwent abdominal hysterectomy were included in the study and randomly divided into 3 groups in a doubled-blinded manner. They were given 150 mg of pregabalin (group P300, n = 30), 300 mg of pregabalin (group P600, n = 30), or placebo capsules (group C, n = 30) 4 hours before the induction of anesthesia; they received a second dose of the drug 12 hours postoperatively. Morphine consumption, nausea, and vomiting, visual analogue scale-pain intensity (VAS-PI), sedation scores, and dissatisfaction scores were recorded in the postanesthesia care unit (PACU) and at 2, 4, 6, and 24 hours after operation.RESULTS: Morphine consumption at 24 hours was 40.80 (3-42) mg, 33.79 (5.77) mg, and 46.97 (6.67) mg in groups P300, P600, and C, respectively (P < 0.001). VAS-PI scores at movement and at rest in the PACU and at 2, 4, and 6 hours decreased in group P600 (P < 0.01). In the PACU and at 2, 4, and 6 hours, the sedation scores were increased in group P600 compared with the scores in group C (P < 0.001, P < 0.001, P = 0.01, P = 0.006, respectively). Patient satisfaction was higher in group P600 than in group C for all time points (P < 0.001, P < 0.001, P < 0.001, P = 0.001, P < 0.001, respectively). There were no statistically significant differences between the groups for side effects such as nausea, vomiting, and dizziness (P = 0.58).CONCLUSIONS'. Pregabalin at a total dose of 600 mg, administered before operation and at 12 hours postoperatively after abdominal hysterectomy, reduced morphine consumption and pain intensity and increased patient satisfaction. No significant differences in side effects we...
机译：背景：普瑞巴林的药理作用与其发育前身加巴喷丁的药理学特征相似，但在神经性疼痛的啮齿动物模型中显示出更高的镇痛活性。目的：本研究的目的是比较两种不同剂量的普瑞巴林和安慰剂对术后的影响方法：90例行腹部子宫切除术的患者被纳入研究，并以双盲方式随机分为3组。在麻醉诱导前4小时给他们服用150mg普瑞巴林（P300组，n = 30），300mg普瑞巴林（P600组，n = 30）或安慰剂胶囊（C组，n = 30）;他们在术后12小时接受了第二剂药物。在麻醉后护理单元（PACU）以及术后2、4、6和24小时记录吗啡的消耗量，恶心和呕吐，视觉类似的疼痛程度（VAS-PI），镇静分数和不满​​意分数。结果：P300，P600和C组在24小时时的吗啡消耗量分别为40.80（3-42）mg，33.79（5.77）mg和46.97（6.67）mg（P <0.001）。 P600组在PACU的运动和休息时，2、4和6小时时，VAS-PI分数降低（P <0.01）。在PACU和第2、4和6小时，与C组相比，P600组的镇静分数增加（分别为P <0.001，P <0.001，P = 0.01，P = 0.006）。在所有时间点上，P600组的患者满意度均高于C组（分别为P <0.001，P <0.001，P <0.001，P = 0.001，P <0.001）。两组之间在诸如恶心，呕吐和头晕等副作用方面没有统计学上的显着差异（P = 0.58）。普瑞巴林总剂量为600 mg，在术前和腹部子宫切除术后12小时给予，减少了吗啡的消耗和疼痛强度，并提高了患者的满意度。我们的副作用无明显差异。

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