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首页> 外文期刊>Current therapeutic research, clinical and experimental. >Erythropoietin Improves the Healing of Skin Necrosis Resulting From Doxorubicin Extravasation in a Rat Model
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Erythropoietin Improves the Healing of Skin Necrosis Resulting From Doxorubicin Extravasation in a Rat Model

机译：促红细胞生成素改善阿霉素外渗引起的大鼠模型皮肤坏死的愈合

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BACKGROUND: Doxorubicin is an antineoplastic agent that causes skin necrosis when extravasated. Various agents have been tried to reduce tissue damage owing to extravasation. Erythropoietin (EPO) is an obligatory growth factor for red blood cells and has beneficial effects on wound healing.OBJECTIVE: The aim of this study was to test the hypothesis that local EPO injection can prevent and improve healing of necrosis at the doxorubicin injection site in rats.METHODS: We used 31 female Sprague-Dawley rats. The dorsal area of each rat was shaved, and 2 mg of doxorubicin in 0.5 mL saline was injected intradermally. The rats were then divided into 3 groups: control; control with intradermal injection of saline; and treatment, which received an intradermal injection of EPO. EPO in saline was injected into 4 quadrants of the same site where doxorubicin was injected 1 hour before. The rats were monitored and the area of each ulcer was measured. Skin biopsies were excised at the end of 4 weeks using anesthetic pentobarbital. Inflammation, edema, epithelization, neovascularization, necrosis, fibroblast proliferation, and collagen synthesis were evaluated and compared between groups.RESULTS: The average areas of the lesions were significantly smaller in the EPO-injected rats (P = 0.03). The histopathologic evaluation revealed that the scores for epithelization, neovascularization, fibroblast proliferation, and collagen synthesis were higher (P < 0.001, P < 0.001, P = 0.002, and P = 0.04, respectively) and the score for necrosis was lower (P < 0.001) in the EPO-injected group than in both the saline-injected and control groups. CONCLUSIONS: In this study using female Sprague-Dawley rats, EPO treatment improved the healing of skin necrosis caused by doxorubicin injection. This finding may lead to a new therapeutic approach for the management of skin necrosis caused by doxorubicin extravasation.
机译：背景：阿霉素是一种抗肿瘤药，在外渗时会引起皮肤坏死。已经尝试了各种试剂来减少由于外渗引起的组织损伤。促红细胞生成素（EPO）是红细胞的必需生长因子，对伤口愈合具有有益作用。目的：本研究的目的是检验以下假设：局部EPO注射可以预防和改善阿霉素注射部位坏死的愈合。方法：我们使用了31只雌性Sprague-Dawley大鼠。将每只大鼠的背部区域剃毛，并在皮内注射0.5mg盐水中的2mg阿霉素。然后将大鼠分为3组：对照组;对照组;和对照组。皮内注射盐水控制并接受了EPO的皮内注射。将盐水中的EPO注射到1小时前注射阿霉素的相同部位的4个象限中。监测大鼠并测量每个溃疡的面积。在4周结束时使用麻醉性戊巴比妥切除皮肤活组织检查。评估并比较各组之间的炎症，水肿，上皮化，新血管形成，坏死，成纤维细胞增殖和胶原蛋白合成。结果：注射EPO的大鼠的平均病灶面积明显较小（P = 0.03）。组织病理学评估显示，上皮化，新血管形成，成纤维细胞增殖和胶原蛋白合成得分较高（分别为P <0.001，P <0.001，P = 0.002和P = 0.04），坏死得分较低（P <注射EPO的组的0.001）比注射生理盐水的组和对照组的0.001。结论：在这项使用雌性Sprague-Dawley大鼠的研究中，EPO治疗改善了由阿霉素注射引起的皮肤坏死的愈合。这一发现可能会导致新的治疗方法来处理由阿霉素外渗引起的皮肤坏死。

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