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首页> 外文期刊>Aging cell. >Lgr5(+) amacrine cells possess regenerative potential in the retina of adult mice
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Lgr5(+) amacrine cells possess regenerative potential in the retina of adult mice

机译：Lgr5（+）amacrine细胞在成年小鼠的视网膜中具有再生潜能

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Current knowledge indicates that the adult mammalian retina lacks regenerative capacity. Here, we show that the adult stem cell marker, leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5), is expressed in the retina of adult mice. Lgr5(+) cells are generated at late stages of retinal development and exhibit properties of differentiated amacrine interneurons (amacrine cells). Nevertheless, Lgr5(+) amacrine cells contribute to regeneration of new retinal cells in the adult stage. The generation of new retinal cells, including retinal neurons and Muller glia from Lgr5(+) amacrine cells, begins in early adulthood and continues as the animal ages. Together, these findings suggest that the mammalian retina is not devoid of regeneration as previously thought. It is rather dynamic, and Lgr5(+) amacrine cells function as an endogenous regenerative source. The identification of such cells in the mammalian retina may provide new insights into neuronal regeneration and point to therapeutic opportunities for age-related retinal degenerative diseases.
机译：当前的知识表明，成年哺乳动物的视网膜缺乏再生能力。在这里，我们显示成年干细胞标记，富含亮氨酸的重复序列包含的G蛋白偶联受体5（Lgr5）在成年小鼠的视网膜中表达。 Lgr5（+）细胞在视网膜发育的后期阶段产生，并表现出分化的无长突神经元（amacrine细胞）的特性。尽管如此，Lgr5（+）amacrine细胞在成年阶段有助于新的视网膜细胞的再生。新的视网膜细胞，包括视网膜神经元和来自Lgr5（+）无长突细胞的穆勒胶质细胞的生成，始于成年初期，并随着动物年龄的增长而持续。总之，这些发现表明，哺乳动物的视网膜并非没有先前所认为的再生。它是相当动态的，Lgr5（+）无长突细胞起内源性再生源的作用。哺乳动物视网膜中此类细胞的鉴定可以为神经元再生提供新的见识，并为与年龄有关的视网膜变性疾病提供治疗机会。

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