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首页> 外文期刊>Current therapeutic research, clinical and experimental. >Effects of Dibutyryl Cyclic Adenosine Monophosphate on Hypercapnic Depression of Diaphragmatic Contractility in Pentobarbital-Anesthetized Dogs
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Effects of Dibutyryl Cyclic Adenosine Monophosphate on Hypercapnic Depression of Diaphragmatic Contractility in Pentobarbital-Anesthetized Dogs

机译：二丁酰基环腺苷一磷酸对戊巴比妥麻醉犬Hyper肌收缩性高碳酸血症性抑郁的影响

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BACKGROUND: Hypercapnia is associated with diaphragm muscle dysfunction that causes a reduction of diaphragmatic force generated for a constant elective myo-graphic activity. No published data are available concerning hypercapnic depression of diaphragmatic contractility during dibutyryl cyclic adenosine monophospate (DBcAMP) administration.OBJECTIVE: The aim of this study was to assess the effects of DBcAMP on hypercapnic depression of diaphragmatic contractility in pentobarbital-anesthetized dogs.METHODS: This experimental study was conducted from July to December 2008 at the Department of Anesthesiology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan. Adult (aged >5 years) mongrel dogs weighing 10 to 15 kg were randomly divided into 3 equal groups. Hypercapnia (80-90 mm Hg) was induced with 10% carbon dioxide added to the inspired gas. When hypercapnia was established, group 1 was infused with low-dose DBcAMP (0.05 mg/kg/min); group 2 was infused with high-dose DBcAMP (0.2 mg/kg/min); and group 3 received placebo (saline). Study drug was administered intravenously for 60 minutes. Diaphragmatic contractility was assessed by transdiaphragmatic pressure (Pdi) at baseline, induction of hypercapnia, and study drug administration.RESULTS: Twenty-one dogs were divided into 3 groups of 7. There were no significant differences observed at baseline. In the presence of hypercapnia, Pdi (mean [SD], cm H_2O) at low- (20-Hz) and high-frequency (100-Hz) stimulation was significantly decreased from baseline in each group (all, P = 0.001). In groups 1 and 2, Pdi at both stimuli was significantly increased during DBcAMP administration compared with hypercapnia-induced values (group 1: 20-Hz, 13.5 [2.2] vs 15.0 [2.4], respectively, P = 0.001, 100-Hz, 21.2 [1.6] vs 22.5 [1.6], P = 0.001; group 2: 20-Hz, 13.7 [1.4] vs 19.2 [1.7], P = 0.001, 100-Hz, 21.0 [2.4] vs 27.2 [2.5], P = 0.001). The Pdi at both stimuli during DBcAMP administration was significantly higher in group 2 than in group 1 (20-Hz, 19.2 [1.7] vs 15.0 [2.4], P = 0.001, 100-Hz, 27.2 [2.5] vs 22.5 [1.6], P = 0.003). In group 3, Pdi did not significantly change in regard to either stimulus from hypercapnia-induced values.CONCLUSION: DBcAMP, in a dose-dependent manner, was associated with improved hypercapnic depression of diaphragmatic contractility in these pentobarbital-anesthetized dogs.
机译：背景：高碳酸血症与diaphragm肌功能障碍有关，后者会降低为持续进行选择性肌电图活动而产生的diaphragm肌力。目的：本研究的目的是评估DBcAMP对戊巴比妥麻醉的犬diaphragm肌收缩能力的高碳酸血症性抑郁症的影响。实验研究于2008年7月至12月在日本筑波大学临床医学研究所麻醉学系进行。将体重在10到15公斤之间的成年（年龄大于5岁）杂种犬随机分为3组。向吸入气体中添加10％的二氧化碳会诱发高碳酸血症（80-90 mm Hg）。建立高碳酸血症时，第1组输注低剂量DBcAMP（0.05 mg / kg / min）;第2组注入大剂量DBcAMP（0.2 mg / kg / min）;第3组接受安慰剂（盐水）。静脉内给予研究药物60分钟。通过基线时的trans肌压力（Pdi），诱发高碳酸血症和研究药物的给药评估assessed肌收缩力。结果：21只狗分为3组，每组7只。基线时无明显差异。在存在高碳酸血症的情况下，每组的低（20-Hz）和高（100-Hz）刺激下的Pdi（平均值[SD]，cm H_2O）均较基线显着降低（所有，P = 0.001）。在第1组和第2组中，与高碳酸血症引起的值相比，在DBcAMP给药期间，两种刺激下的Pdi均显着增加（第1组：20 Hz，13.5 [2.2]和15.0 [2.4]，P = 0.001、100 Hz， 21.2 [1.6] vs 22.5 [1.6]，P = 0.001;第二组2：20 Hz，13.7 [1.4] vs 19.2 [1.7]，P = 0.001，100 Hz，21.0 [2.4] vs 27.2 [2.5]，P = 0.001）。第2组在DBcAMP给药期间两种刺激下的Pdi均显着高于第1组（20 Hz，19.2 [1.7] vs 15.0 [2.4]，P = 0.001、100 Hz，27.2 [2.5] vs 22.5 [1.6] ，P = 0.003）。在第3组中，高碳酸血症引起的值对Pdi的刺激均无显着改变。结论：DBcAMP以剂量依赖性方式与这些戊巴比妥麻醉的狗的高碳酸血症性diaphragm肌收缩能力降低相关。

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