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首页> 外文期刊>Aging cell. >Haploinsufficiency of myostatin protects against aging-related declines in muscle function and enhances the longevity of mice
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Haploinsufficiency of myostatin protects against aging-related declines in muscle function and enhances the longevity of mice

机译：肌生成抑制素的单倍剂量不足可防止与衰老相关的肌肉功能下降并延长小鼠的寿命

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The molecular mechanisms behind aging-related declines in muscle function are not well understood, but the growth factor myostatin (MSTN) appears to play an important role in this process. Additionally, epidemiological studies have identified a positive correlation between skeletal muscle mass and longevity. Given the role of myostatin in regulating muscle size, and the correlation between muscle mass and longevity, we tested the hypotheses that the deficiency of myostatin would protect oldest-old mice (28-30months old) from an aging-related loss in muscle size and contractility, and would extend the maximum lifespan of mice. We found that MSTN+/- and MSTN-/- mice were protected from aging-related declines in muscle mass and contractility. While no differences were detected between MSTN+/+ and MSTN-/- mice, MSTN+/- mice had an approximately 15% increase in maximal lifespan. These results suggest that targeting myostatin may protect against aging-related changes in skeletal muscle and contribute to enhanced longevity.
机译：衰老相关的肌肉功能下降背后的分子机制尚不清楚，但生长因子肌生长抑制素（MSTN）在此过程中似乎起着重要作用。此外，流行病学研究已发现骨骼肌质量与寿命之间存在正相关。考虑到肌肉生长抑制素在调节肌肉大小中的作用以及肌肉质量和寿命之间的相关性，我们检验了肌肉生长抑制素缺乏可保护年龄最大的小鼠（28-30个月大）免受衰老相关的肌肉尺寸和体重损失的假说。收缩力，并会延长小鼠的最大寿命。我们发现，MSTN +/-和MSTN-/-小鼠免受衰老相关的肌肉质量和收缩力下降的影响。虽然在MSTN + / +和MSTN-/-小鼠之间未检测到差异，但MSTN +/-小鼠的最大寿命增加了约15％。这些结果表明，靶向肌生长抑制素可以预防骨骼肌衰老相关的变化，并有助于延长寿命。

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