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首页> 外文期刊>Aging cell. >Interventions to Slow Aging in Humans: Are We Ready?
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Interventions to Slow Aging in Humans: Are We Ready?

机译：减慢人类衰老的干预措施：我们准备好了吗？

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摘要

The workshop entitled 'Interventions to Slow Aging in Humans: Are We Ready?' was held in Erice, Italy, on October 8-13, 2013, to bring together leading experts in the biology and genetics of aging and obtain a consensus related to the discovery and development of safe interventions to slow aging and increase healthy lifespan in humans. There was consensus that there is sufficient evidence that aging interventions will delay and prevent disease onset for many chronic conditions of adult and old age. Essential pathways have been identified, and behavioral, dietary, and pharmacologic approaches have emerged. Although many gene targets and drugs were discussed and there was not complete consensus about all interventions, the participants selected a subset of the most promising strategies that could be tested in humans for their effects on healthspan. These were: (i) dietary interventions mimicking chronic dietary restriction (periodic fasting mimicking diets, protein restriction, etc.); (ii) drugs that inhibit the growth hormone/IGF-I axis; (iii) drugs that inhibit the mTOR-S6K pathway; or (iv) drugs that activate AMPK or specific sirtuins. These choices were based in part on consistent evidence for the pro-longevity effects and ability of these interventions to prevent or delay multiple age-related diseases and improve healthspan in simple model organisms and rodents and their potential to be safe and effective in extending human healthspan. The authors of this manuscript were speakers and discussants invited to the workshop. The following summary highlights the major points addressed and the conclusions of the meeting.
机译：研讨会名为“干预人类慢衰老：我们准备好了吗？”该会议于2013年10月8日至13日在意大利埃里塞举行，汇集了衰老的生物学和遗传学方面的领先专家，并就发现和开发安全的干预措施达成共识，以减缓衰老并延长人类健康寿命。人们一致认为，有足够的证据表明，对于许多成人和老年人的慢性病，​​老化的干预措施将延迟并预防疾病的发作。已经确定了基本途径，并且出现了行为，饮食和药理学方法。尽管讨论了许多基因靶点和药物，并且尚未就所有干预措施达成完全共识，但参与者选择了可以在人体中测试其对健康跨度影响的最有希望的策略的子集。它们是：（i）模仿慢性饮食限制的饮食干预措施（模仿饮食的定期禁食，蛋白质限制等）; （ii）抑制生长激素/ IGF-I轴的药物; （iii）抑制mTOR-S6K途径的药物; （iv）激活AMPK或特定沉默调节蛋白的药物。这些选择部分基于一致的证据，这些证据对这些干预措施具有预防寿命或延缓多种与年龄有关的多种疾病并改善简单模型生物和啮齿动物健康状况的能力，以及其安全有效地延长人类健康寿命的潜力。该手稿的作者是受邀参加研讨会的演讲者和讨论者。以下摘要强调了要解决的重点和会议的结论。

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