Interplay between O-GlcNAcylation and phosphorylation of proteins has been likened to a yin-yang concept,where an increase in one modification can correlate with a decrease in the other.With respect to the tumor suppressor protein p53,phosphorylation can stabilize the protein by decreasing its degradation via the ubiquitin-proteasome pathway.Although p53 is also O-GlcNAcylated,the sites of O-GlcNAcylation and its effects on p53 function are not well-defined.Now,Yang et a I.[Nat.Cell Biol.2006,8,1074-1083)use the small-molecule O-GlcNAcase inhibitor streptozotocin(STZ)to provide insight into the role of O-GlcNAcylation in p53 regulation and the codependent relationship of p53 O-GlcNAcylation and phosphorylation.
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