Oxidative Modification of Ca~(2+)Channels,Ryanodine Receptors, and the Sarco/Endoplasmic Reticulum Ca~(2+)-ATPase

Victor S. Sharov; Christian Schoneich

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Oxidative Modification of Ca~(2+)Channels,Ryanodine Receptors, and the Sarco/Endoplasmic Reticulum Ca~(2+)-ATPase

机译：Ca〜（2+）通道，Ryanodine受体和Sarco /内质网Ca〜（2 +）-ATPase的氧化修饰

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This paper reviews our current knowledge on the oxidative modifications of mem-brane proteins implicated in Ca~(2+)transport. The high sensitivity of some Ca~(2+)handling proteins, such as the L-type voltage-gated channel, the ryanodine re-ceptor, and the sarco/endoplasmic reticulum Ca~(2+)-ATPase (SERCA) to oxidativemodifications renders them important targets for oxidative regulation/modulationendowing a crosstalk between redox signaling and calcium transients in the cell.The main focus of this review is to correlate either loss or gain of protein functionunder conditions of oxidative stress to selective, potentially reversible, modifica-tions of specific amino acids. Among those special emphasis will be placed onS-nitrosation, S-glutathiolation, disulfide formation, and Tyr nitration, as poten-tial mechanism of redox-dependent signaling in the cell.

机译：本文综述了我们目前对涉及Ca〜（2+）转运的膜蛋白的氧化修饰的认识。某些Ca〜（2+）处理蛋白（如L型电压门控通道，雷诺丁受体和肌浆网/内质网Ca〜（2 +）-ATPase（SERCA））对氧化修饰具有很高的敏感性由于氧化还原信号和细胞内钙瞬变之间存在串扰，因此使它们成为氧化调节/调节的重要靶标。本综述的主要重点是将氧化应激条件下蛋白质功能的丧失或获得与选择性的，可能可逆的修饰相关联。特定氨基酸。作为细胞中氧化还原依赖性信号转导的潜在机制，将特别强调S-亚硝化，S-谷氨酰胺化，二硫键形成和Tyr硝化。

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《Current topics in membranes》 |2008年第null期|共18页
作者
Victor S. Sharov; Christian Schoneich;
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正文语种 eng
中图分类细胞生物学;
关键词
Ryanodine Receptors; Endoplasmic Reticulum; Ca~(2+)-ATPase;

机译：Ryanodine受体;内质网;Ca〜（2 +）-ATPase;

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专利

1. Oxidative Modification of Ca~(2+)Channels,Ryanodine Receptors, and the Sarco/Endoplasmic Reticulum Ca~(2+)-ATPase [J] . Victor S. Sharov, Christian Schoneich Current topics in membranes . 2008,第Null期

机译：Ca〜（2+）通道，Ryanodine受体和Sarco /内质网Ca〜（2 +）-ATPase的氧化修饰
2. Ca~(2+)-ATPases in non-failing and failing heart: evidence for a novel cardiac sarco/endoplasmic reticulum Ca~(2+)-ATPase 2 isoform (SERCA2c) [J] . Saoussen DALLY, Raymonde BREDOUX, Elisabeth CORVAZIER, The Biochemical Journal . 2006,第2期

机译：未衰竭和衰竭的心脏中的Ca〜（2 +）-ATPases：新型心肌肌/内质网Ca〜（2 +）-ATPase 2亚型（SERCA2c）的证据
3. Anticancer Ruthenium(III) Complex KP1019 Interferes with ATP-Dependent Ca~(2+) Translocation by Sarco-Endoplasmic Reticulum Ca~(2+)-ATPase (SERCA) [J] . Fabrizio-Zagros Sadafi, Lara Massai, Gianluca Bartolommei ChemMedChem . 2014,第8期

机译：抗癌钌（III）配合物KP1019通过肌浆网内Ca〜（2 +）-ATPase（SERCA）干扰ATP依赖的Ca〜（2+）转运。
4. Reconstitution of Ryanodine Receptor/Ca~(2+) Release Channels in S-layer Supported Lipid Membranes [C] . Vanessa-Dominique Larisch, Angelika Schrems, Uwe B. Sleytr, International Conference on Quantum, Nano/Bio, and Micro Technologies . 2014

机译：在S层中重构ryanodine受体/ Ca〜（2+）释放通道的脂质膜
5. Generation and analysis of mice lacking (sarco)endoplasmic reticulum calcium(2+)-ATPase isoform 3 (SERCA3) [D] . Liu, Lynne Hofelich 1998

机译：缺乏（肌氨酸）内质网钙（2 +）-ATPase同工型3（SERCA3）的小鼠的产生和分析
6. Ca2+ increase and Ca(2+)-influx in human tracheal smooth muscle cells: role of Ca2+ pools controlled by sarco-endoplasmic reticulum Ca(2+)-ATPase 2 isoform. [O] . Y. Amrani, C. Magnier, J. Enouf, 1995

机译：Ca2 +增加和人类气管平滑肌细胞中的Ca（2+）流入：肌质内质网Ca（2 +）-ATPase 2亚型控制的Ca2 +池的作用。
7. The N Terminus of Sarcolipin Plays an Important Role in Uncoupling Sarco-endoplasmic Reticulum Ca²⁺-ATPase (SERCA) ATP Hydrolysis from Ca²⁺ Transport [O] . Sahoo, Sanjaya K, Shaikh, Sana A, Sopariwala, Danesh H, 2015

机译：肌钙蛋白的N末端在解耦肌浆网内膜Ca ^{2 + -ATPase（SERCA）ATP从Ca ^{2 + 转运水解中起重要作用}}
8. Cyclic AMP Stimulation of Membrane Phosphorylation and Ca(2+)-Activated, Mg(2+)-Dependent ATPase in Cardiac Sarcoplasmic Reticulum. [R] . Wray, H. L., Gray, R. R. 1976

机译：环磷酸腺苷对心肌肌浆网中膜磷酸化和Ca（2 +）激活的mg（2+）依赖性aTp酶的刺激作用。

Oxidative Modification of Ca~(2+)Channels,Ryanodine Receptors, and the Sarco/Endoplasmic Reticulum Ca~(2+)-ATPase

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