Effects of Nitrogen Oxides on Chloride Channels

Benjamin Gaston

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Effects of Nitrogen Oxides on Chloride Channels

机译：氮氧化物对氯离子通道的影响

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Abnormal chloride (Cl~-) channel activity underlies the pathophysiology of several human diseases. Recently, it has been appreciated that nitric oxide syn-thase (NOS) activation and/or treatment with exogenous nitrogen oxides (NO_x)can modify the expression, maturation and/or function of a variety of Cl~- channel proteins, including the cystic fibrosis (CF) transmembrane regulatory protein(CFTR). Mechanisms underlying these effects are both cyclic GMP (cGMP)-dependent and cGMP-independent. A more detailed molecular understanding ofthese mechanisms may enable targeting of Cl~- channels in the development of new therapies.

机译：氯离子（Cl〜-）通道活性异常是几种人类疾病的病理生理基础。最近，已经认识到一氧化氮合酶（NOS）的活化和/或用外源氮氧化物（NO_x）的处理可以改变包括囊性蛋白在内的多种Cl-通道蛋白的表达，成熟和/或功能。纤维化（CF）跨膜调节蛋白（CFTR）。产生这些作用的机制既依赖于循环GMP（cGMP），也依赖于cGMP。对这些机制的更详细的分子理解可以使得在开发新疗法中靶向Cl-通道成为可能。

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《Current topics in membranes》 |2008年第null期|共16页
作者
Benjamin Gaston;
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正文语种 eng
中图分类细胞生物学;
关键词
Nitrogen Oxides; Chloride Channels; cyclic GMP;

机译：氮氧化物;氯离子通道;循环GMP;

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1. Effects of Nitrogen Oxides on Chloride Channels [J] . Benjamin Gaston Current topics in membranes . 2008,第Null期

机译：氮氧化物对氯离子通道的影响
2. Chloride intracellular channel 1 (CLIC1): Sensor and effector during oxidative stress. [J] . Averaimo S, Milton RH, Duchen MR, FEBS letters. . 2010,第10期

机译：氯化物细胞内通道1（CLIC1）：氧化应激期间的传感器和效应器。
3. Chloride intracellular channel 1 (CLIC1): Sensor and effector during oxidative stress [J] . FEBS Letters . 2010,第10期

机译：氯离子细胞内通道1（CLIC1）：氧化应激期间的传感器和效应子
4. Aircraft Trajectory Design Based on Reducing the Combined Effects of Carbon-Dioxide, Oxides of Nitrogen and Contrails [C] . Banavar Sridhar, Neil Y. Chen, Hok K. Ng AIAA modeling and simulation technologies conference;AIAA SciTech forum . 2014

机译：基于减少二氧化碳，氮氧化物和轨迹变化综合影响的飞机弹道设计
5. Computer simulations of the structure, stability and phase transitions of diatomic molecules physisorbed on ionic surfaces: the carbon monoxide/magnesium oxide(001), nitrogen/magnesium oxide(001) and nitrogen/sodium chloride(001) systems. [D] . Sallabi, Abdulwahab K. 2002

机译：离子表面上物理吸附的双原子分子的结构，稳定性和相变的计算机模拟：一氧化碳/氧化镁（001），氮/氧化镁（001）和氮/氯化钠（001）系统。
6. Chloride is an allosteric effector of copper assembly for the yeast multicopper oxidase Fet3p: An unexpected role for intracellular chloride channels [O] . Sandra R. Davis-Kaplan, Candice C. Askwith, Andrea C. Bengtzen, 1998

机译：氯化物是酵母多铜氧化酶Fet3p的铜装配的变构效应物：细胞内氯通道的意外作用
7. Chloride intracellular channel 1 (CLIC1): Sensor and effector during oxidative stress [O] . Averaimo Stefania, Milton Rosemary H., Duchen Michael R., 2010

机译：氯离子细胞内通道1（CLIC1）：氧化应激期间的传感器和效应子
8. A STUDY OF EQUILIBRIA INVOLVED BETWEEN DAREX OFF-GASES AND SOLUTIONS A Literature Survey on the Solubility of Argon, Chlorine, Hydrogen Chloride, Nitric Oxide, Nitrogen, Nitrogen Dioxide, Nitrous Oxide and Oxygen in Water, Nitric Acid, Hydrochloric Acid and Aqua Regla [R] . THOMAS W. WILSON 1959

机译：DaREX废气与溶液相关的平衡研究 - 水，硝酸，盐酸和aqua Regla中氩，氯，氯化氢，一氧化氮，氮，二氧化氮，一氧化二氮和氧的溶解度的文献综述

Effects of Nitrogen Oxides on Chloride Channels

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