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首页> 外文期刊>American journal of rhinology >Polymorphism at the glutathione S-transferase P1 locus in Korean patients with perennial allergic rhinitis.
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Polymorphism at the glutathione S-transferase P1 locus in Korean patients with perennial allergic rhinitis.

机译：多年生过敏性鼻炎韩国患者谷胱甘肽S-转移酶P1位点的多态性。

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BACKGROUND: Oxidative stresses, which induce the reactive oxygen species (ROS), can cause airway inflammation. The glutathione S-transferases (GSTs) protect cells against the effects of ROS. GSTP1 polymorphism may have some effect on allergic rhinitis. Therefore, we have compared the effects of GSTP1 polymorphisms on the perennial allergic rhinitis in Koreans. METHODS: Patients with perennial allergies (149 patients) were selected. The control group included 156 healthy people. Genotypes were evaluated via polymerase chain reaction and restriction fragment length polymorphism, using the Alw26I restriction enzyme. RESULTS: There was no significant difference between groups in the proportions of the Ile/Ile (wild type) and Ile/Val (heterozygote) genotypes. However, the Val/Val (mutant type homozygote) was expressed in only one case (0.7%) in the perennial allergic rhinitis group, as compared with 11 cases (7.1%) in the controls (p < 0.05). CONCLUSION: Our results indicate that the Val/Val genetic polymorphism of GSTP1 may exert some protective effects in allergic inflammation.
机译：背景：氧化应激会诱发活性氧（ROS），可能导致气道炎症。谷胱甘肽S-转移酶（GST）保护细胞免受ROS的影响。 GSTP1基因多态性可能对过敏性鼻炎有一定影响。因此，我们比较了GSTP1基因多态性对韩国人常年性变应性鼻炎的影响。方法：选择常年性过敏的患者（149例）。对照组包括156名健康人。使用Alw26I限制酶通过聚合酶链反应和限制片段长度多态性评估基因型。结果：Ile / Ile（野生型）和Ile / Val（杂合子）基因型的比例在两组之间没有显着差异。但是，常年性变应性鼻炎组中只有1例（0.7％）出现了Val / Val（突变型纯合子），而对照组中只有11例（7.1％）（p <0.05）。结论：我们的结果表明GSTP1的Val / Val遗传多态性可能对过敏性炎症具有一定的保护作用。

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