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首页> 外文期刊>American journal of rhinology >The effects of zinc on the olfactory neuroepithelium and olfactory bulbs of the Sprague-Dawley rat after oral administration of zinc-gluconate trihydrate.
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The effects of zinc on the olfactory neuroepithelium and olfactory bulbs of the Sprague-Dawley rat after oral administration of zinc-gluconate trihydrate.

机译：锌对三水葡萄糖酸锌口服给药后对Sprague-Dawley大鼠嗅神经上皮和嗅球的影响。

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BACKGROUND: The most frequent causes of upper respiratory infections are human rhinoviruses. The nasopharyngeal area, which includes the respiratory epithelium, mucosa, and the olfactory neuroepithelium (ONe), is a first-line of defense against airborne viruses and allergens, some of which manage to penetrate the nasal mucosa and invade the tissues of the nasal respiratory epithelium. Biochemical evidence from several studies suggests that zinc is an effective cold treatment and that over-the-counter (OTC) zinc-gluconate compounds may provide the high pharmacologic doses of zinc needed to act as an effective means of treating and reducing the duration and severity of symptoms of the common cold. METHODS: A series of male Sprague-Dawley rats were fed an oral preparation of zinc-gluconate trihydrate or received the equivalent through drinking water to investigate the potential cytotoxic and/or neurotoxic insult to the olfactory receptor cells and other tissue in the ONe and afferent neuronal pathways. RESULTS: Coronal sections of the rat ONe and corresponding olfactory bulbs showed consistent cellular and tissue damage of increasing severity that correlated with the duration of treatment with the zinc compound when compared with the control group animals. CONCLUSION: The results of this analysis indicate that the repeated oral administration of such zinc-containing compounds have neurotoxic effects on the ONe and to the mitral cells in the olfactory bulbs of treated rats. These findings point toward the need for increased investigation into the potential deleterious effects of zinc-containing compounds to humans as well.
机译：背景：上呼吸道感染的最常见原因是人鼻病毒。鼻咽区域包括呼吸道上皮，粘膜和嗅觉神经上皮（ONe），是抵抗空中传播的病毒和过敏原的第一道防线，其中一些病毒设法穿透鼻粘膜并侵袭鼻呼吸道组织上皮。来自数项研究的生化证据表明，锌是一种有效的感冒药，场外（OTC）葡萄糖酸锌化合物可提供所需的高锌药理剂量，以作为治疗和减少病程和严重程度的有效手段普通感冒的症状。方法：给一系列雄性Sprague-Dawley大鼠喂食口服三水合葡萄糖酸锌制剂或通过饮用水接受等效剂量，以研究其对嗅觉受体细胞及其他组织中嗅觉感受器和其他组织的潜在细胞毒性和/或神经毒性损害。神经元通路。结果：与对照组动物相比，大鼠ONe的冠状切片和相应的嗅球显示出持续的细胞和组织损伤，其严重程度与锌化合物的治疗时间长短有关。结论：该分析结果表明，反复口服此类含锌化合物对被治疗大鼠的嗅球中的ONe和二尖细胞具有神经毒性作用。这些发现表明，有必要进一步研究含锌化合物对人类的潜在有害作用。

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