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首页> 外文期刊>American journal of rhinology >Severe chemotherapy-induced parosmia.
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Severe chemotherapy-induced parosmia.

机译：严重的化学疗法诱发的妄想症。

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BACKGROUND: Smell and taste disorders are among the side effects of chemo- and radiotherapy. Although direct radionecrosis of the salivary glands and the taste buds might explain the chemosensory problems after radiotherapy, the olfactory and gustatory complaints seen after chemotherapy remain unexplained. The patients reporting olfactory symptoms rarely complain about qualitative olfactory disorders such as parosmia or phantosmia. Quantitative olfactory loss such as anosmia and hyposmia seem to be more frequent. METHODS: We present the case of a 63-year-old woman with chemotherapy-induced parosmia leading to severe nutrition and appetite problems resulting in a life-threatening weight loss. RESULTS: With the aid of a simple nose clip the parosmia could be abolished and oral food intake became possible again. Parosmia resolved gradually over an observation period of 9 months, in parallel to an increase of olfactory sensitivity. The patient progressively gained appetite and weight. CONCLUSION: Parosmia can occur as a severe and potentially life-threatening complication of chemotherapy. This rare presentation of parosmia illustrates the importance of olfactory testing with an adequate recognition of the underlying problem and a consecutive treatment.
机译：背景：气味和味觉障碍是化学疗法和放射疗法的副作用之一。尽管唾液腺直接放射性坏死和味蕾可能解释了放疗后的化学感觉问题，但化疗后出现的嗅觉和味觉不适仍无法解释。报告嗅觉症状的患者很少抱怨定性嗅觉障碍，例如妄想症或幻觉症。嗅觉丧失（如失眠和低渗）似乎更为频繁。方法：我们介绍了一名63岁的女性，因化疗引起的妄想症，导致严重的营养和食欲问题，从而危及生命，体重减轻。结果：借助简单的鼻夹，可以消除轻瘫，并且可以再次摄入口腔食物。在9个月的观察期内，妄想症逐渐消退，与此同时，嗅觉敏感性也有所提高。病人逐渐增加食欲和体重。结论：妄想症可作为严重的并可能威胁生命的化疗并发症发生。这种稀有的口臭症表现出嗅觉测试的重要性，必须充分认识潜在的问题并进行连续治疗。

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