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首页> 外文期刊>American journal of rhinology >Do nasal polyps and inverted papilloma have similar disorders in cell cycle regulation?
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Do nasal polyps and inverted papilloma have similar disorders in cell cycle regulation?

机译：鼻息肉和乳头状乳头状瘤在细胞周期调节方面是否有相似的疾病？

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BACKGROUND: The aim of this study was to determine the expression of cell cycle regulation genes in patients with inverted papilloma (IP) and compare this with expression in patients with nasal polyps (NPs). METHODS: Tissue from 18 patients with IP and 5 patients with NPs were stained by immunohistochemistry techniques for p53 and p27. Measurement of the gene expression was performed by three assessors, who we blinded with respect to the specimens. RESULTS: The mean score for p53 expression (3.33) was significantly higher in the IP group than the NP group (1.46). The mean difference between IP and NPs was 1.80 (CI, 1.15-2.46; p = 0.003). Additionally, we showed in a number of individuals variation in the p53 expression within the same specimen. There was no difference in the mean scores for p27, with the mean difference 0.79 (CI, 0.30-1.89; p = 0.147). CONCLUSION: Our study established a significantly increased expression of p53 in IP when compared with NPs. Additionally, there appear to be two different cell populations identified within the same specimens, which exhibited variation in their p53 expression.
机译：背景：这项研究的目的是确定细胞周期调控基因在乳头状乳头状瘤（IP）患者中的表达，并将其与鼻息肉（NPs）患者中的表达进行比较。方法：采用免疫组织化学技术对18例IP患者和5 NP患者的组织进行p53和p27染色。基因表达的测量由三名评估者进行，我们对样本不知情。结果：IP组p53表达的平均得分（3.33）显着高于NP组（1.46）。 IP和NP之间的平均差为1.80（CI，1.15-2.46; p = 0.003）。另外，我们在同一样本中的许多个体中显示了p53表达的变异。 p27的平均得分没有差异，平均差异为0.79（CI，0.30-1.89; p = 0.147）。结论：我们的研究确定了与NP相比，p53在IP中的表达显着增加。此外，在同一样本中似乎鉴定出两个不同的细胞群，它们在p53表达中表现出差异。

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