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首页> 外文期刊>American journal of rhinology >Rehabilitation of surgically traumatized paranasal sinus mucosa using retinoic acid.
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Rehabilitation of surgically traumatized paranasal sinus mucosa using retinoic acid.

机译：使用维甲酸修复外科创伤性副鼻窦黏膜。

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BACKGROUND: Paranasal sinus mucosa that regenerates after surgical stripping is characterized by sparse, dysmorphic cilia. Although such dysfunctional mucosal changes are thought to be irreversible, the potential rehabilitation of deciliated mucosa by topical therapies has not been explored. This study evaluated the effect of topical retinoic acid (RA) in rehabilitating deciliated sinus mucosa that has regenerated after surgical stripping. METHODS: Twelve New Zealand rabbits underwent bilateral maxillary sinus mucosal stripping and were allowed to remucosalize for 10 days. In the first treatment arm (n = 6), 0.01% RA was applied to the regenerated mucosa of the left maxillary sinus and an aqueous control was placed contralaterally. In the second treatment arm, the regenerated mucosa was surgically restripped bilaterally before applying RA and control. After 14 additional days, mucosa was harvested and examined by scanning electron microscopy for ciliary density, orientation, and morphology. RESULTS: Inthe first treatment arm, no significant differences in ciliary density, orientation, or morphology were noted between RA-treated sinuses and controls. In the second arm, RA-treated sinuses showed improved ciliary density, morphology, and orientation compared with controls. CONCLUSION: RA does not appear to significantly enhance ciliogenesis when applied after mucosal regeneration has occurred. However, if deciliated mucosa is restripped and allowed to regenerate in the presence of RA, ciliary ultrastructural features may be enhanced. RA may have therapeutic value in rehabilitating deciliated sinus mucosa when applied before mucociliary differentiation of regenerating mucosa.
机译：背景：外科剥离后再生的鼻旁窦粘膜的特征是稀疏，畸形纤毛。尽管这种功能失调的粘膜改变被认为是不可逆的，但是尚未探索通过局部疗法对脱落的粘膜进行潜在的康复。这项研究评估了局部视黄酸（RA）在修复手术剥离后已再生的脱落的鼻窦黏膜中的作用。方法：对十二只新西兰兔进行双侧上颌窦黏膜剥离，并允许其再次黏膜化10天。在第一个治疗组（n = 6）中，将0.01％RA应用于左上颌窦的再生粘膜，并在对侧放置水对照。在第二个治疗组中，在应用RA和对照之前，将手术后的双侧黏膜重新撕开。再过14天后，收获粘膜并通过扫描电子显微镜检查睫状纤毛密度，方向和形态。结果：在第一个治疗组中，RA治疗的鼻窦和对照组之间的睫状密度，方向或形态没有显着差异。在第二臂中，与对照组相比，RA治疗的鼻窦显示出改善的睫状密度，形态和定向。结论：在粘膜再生发生后应用RA似乎不会显着增强纤毛生成。但是，如果剥下脱落的粘膜并在RA存在下使其再生，则可以增强睫状超微结构特征。当在再生粘膜的粘膜纤毛分化之前应用RA时，RA可能具有修复脱落的鼻窦粘膜的治疗价值。

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