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首页> 外文期刊>American journal of rhinology >Allergic fungal sinusitis associated with allergic bronchopulmonary aspergillosis: an uncommon sinobronchial allergic mycosis.
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Allergic fungal sinusitis associated with allergic bronchopulmonary aspergillosis: an uncommon sinobronchial allergic mycosis.

机译：过敏性真菌鼻窦炎与过敏性支气管肺曲霉菌病相关：一种罕见的鼻支气管过敏性真菌病。

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BACKGROUND: The identification of allergic fungal sinusitis (AFS) is still controversial and much more recent than that of allergic bronchopulmonary aspergillosis (ABPA). Their association has been reported very rarely in the literature. METHODS: The aim of this study was to present a review of 6 cases of AFS associated with ABPA from a series of 12 cases of AFS and to compare AFS associated with ABPA and isolated AFS. RESULTS: All cases of AFS presented with chronic rhinosinusitis. The six cases with AFS and ABPA were atopic, asthmatic, with pulmonary infiltrates (five cases), central bronchiectasis (four cases), and both (three cases). The mycological and immunoallergological features of isolated AFS and AFS associated with ABPA were similar: eosinophilic allergic mucin with noninvasive fungi hyphae, high levels of blood eosinophils, total IgE, specific IgE, IgG, and positive skin tests to Aspergillus. The association of AFS and ABPA was concomitant (two cases) or remote in time (four cases). The treatment with oral corticosteroids and sinus surgery (six cases) associated with antifungal drugs (four cases) led to resolution in three cases, considerable improvement in one case, and therapeutic failure in two cases (follow-up longer than 5 years in all cases). CONCLUSION: Independently of the signs linked to the organs involved (sinuses and bronchi) the mycological and immunoallergological features were similar for AFS and AFS associated with ABPA. AFS and ABPA can be isolated or associated in a sinobronchial allergic
机译：背景：过敏性真菌性鼻窦炎（AFS）的鉴定仍存在争议，并且比过敏性支气管肺曲霉菌病（ABPA）的鉴定要新得多。他们的联系在文献中很少被报道。方法：本研究的目的是对一系列12例AFS中的6例与ABPA相关的AFS进行回顾，并比较与ABPA和孤立AFS相关的AFS。结果：所有AFS病例均伴有慢性鼻-鼻窦炎。 AFS和ABPA的6例均为特应性，哮喘，肺浸润（5例），中央支气管扩张（4例）和两者（3例）。分离的AFS和与ABPA相关的AFS的真菌学和免疫变应性特征相似：嗜酸性变应性粘蛋白，无创真菌菌丝，血中嗜酸性粒细胞水平高，总IgE，特异性IgE，IgG以及曲霉菌的皮肤试验阳性。 AFS和ABPA的关联是伴随的（两例）或时间上的偏远（四例）。口服皮质类固醇和鼻窦手术（六例）与抗真菌药（四例）的治疗导致三例消退，其中一例明显改善，两例治疗失败（所有病例的随访时间均超过5年） ）。结论：独立于与所涉及器官（鼻窦和支气管）有关的体征，AFS和与ABPA相关的AFS的真菌学和免疫变应性特征相似。 AFS和ABPA可以分离或与鼻支气管过敏相关

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