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首页> 外文期刊>ACS Macro Letters >How Far Are Single-Chain Polymer Nanoparticles in Solution from the Globular State?
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How Far Are Single-Chain Polymer Nanoparticles in Solution from the Globular State?

机译：溶液中的单链聚合物纳米颗粒距离球状状态有多远？

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Single-chain nanoparticles (SCNPs) are unimolecular soft nano-objects, consisting of individual polymer chains collapsed to a certain degree by means of intramolecular bonding. Many of the potential applications of SCNPs rely on their particular molecular architecture. Even if the ultimate goal is to produce globular protein-like soft nanoparticles, recent small-angle neutron scattering (SANS) and small-angle X-ray scattering (SAXS) resultssupported by computer simulationsindicate that SCNPs in solution actually adopt sparse configurations. Herein we compile size data from the literature for a large number of SCNPs in solu- tion, covering from covalent to noncovalent bonded SCNPs, and provide a comparison with the corresponding data for compact or partially swollen globules of the same nature and molar mass. This comparison gives a clear idea of how far from the compact globule limit are current SCNPs. A quantification of the departure from the globular state is provided in terms of size scaling laws. This procedure facilitates a comparison with the size scaling laws observed for folded proteins with globular conformation as well as intrinsically disordered proteins which, on average, exhibit a certain local compaction when compared to chemically denatured proteins. Lastly, the underlying physical mechanism for the noncompact morphology of SCNPs in solution is put forward, and guidelines for the potential synthesis of true SCNP globules in solution are suggested.
机译：单链纳米颗粒（SCNP）是单分子软纳米物体，由通过分子内键合在一定程度上折叠的单个聚合物链组成。 SCNPs的许多潜在应用都依赖于其特定的分子结构。即使最终目标是生产球状蛋白状的软纳米颗粒，计算机模拟也支持了最近的小角度中子散射（SANS）和小角度X射线散射（SAXS）结果，表明溶液中的SCNP实际上采用稀疏配置。在这里，我们从文献中收集了溶液中大量SCNP的尺寸数据，涵盖了从共价键结合到非共价键的SCNP，并与具有相同性质和摩尔质量的紧密或部分溶胀的小球的相应数据进行了比较。这种比较清楚地表明了当前SCNP距离紧凑球状极限有多远。根据尺寸缩放定律提供了对球状状态偏离的量化。该方法有助于与观察到的具有球形构象的折叠蛋白以及与化学变性蛋白相比平均表现出一定局部致密性的固有无序蛋白的尺寸缩放定律进行比较。最后，提出了溶液中SCNPs非紧缩形态的潜在物理机制，并提出了潜在合成溶液中SCNPs球的潜在指导。

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