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Hydrophobic Plant Antioxidants. Preparation of Nanoparticles and their Application for Prevention of Neurodegenerative Diseases. Review and Experimental Data

机译:疏水性植物抗氧化剂。纳米粒子的制备及其在预防神经退行性疾病中的应用。审查和实验数据

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摘要

There are numerous reports on the role of oxidative stress in the origin of some neurodegenerative (Alzheimer's and Parkinson's) diseases; however, the information concerning molecular mechanisms of the observed effects is rather contradictory. This paper summarizes the review of our own works in this field and new experimental observations on the antioxidant action of some hydrophobic plant compounds. We discuss our hypothesis on the role of misfolded proteins in the regulation of the chaperone system involved in the genesis of amyloid neurodegenerative (prion and Alzheimer's) diseases, briefly describe the role of modification of the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase in the inhibition of glycolysis and induction of the apoptosis of nerve cells, and suggest possible ways of the use of hydrophobic plant antioxidants for the prevention of amyloid transformation of proteins and other neurodegenerative processes.
机译:氧化应激在某些神经退行性疾病(阿尔茨海默氏症和帕金森氏症)的起源中的作用已有大量报道。但是,有关观察到的作用的分子机制的信息却是矛盾的。本文总结了我们在该领域的工作综述,以及一些疏水性植物化合物的抗氧化作用的新实验观察。我们讨论了错折叠蛋白在参与淀粉样神经退行性疾病(Al病毒和阿尔茨海默氏病)发生的分子伴侣系统调节中的作用的假设,简要描述了糖酵解酶甘油醛-3-磷酸脱氢酶的修饰作用糖酵解和诱导神经细胞凋亡的研究,并提出了使用疏水性植物抗氧化剂预防蛋白质淀粉样变性和其他神经变性过程的可能方法。

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