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首页> 外文期刊>Aging clinical and experimental research >Age-related changes in unstimulated salivary function and composition and its relations to medications and oral sensorial complaints.
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Age-related changes in unstimulated salivary function and composition and its relations to medications and oral sensorial complaints.

机译：年龄相关的唾液功能和成分刺激性变化及其与药物和口腔感觉不适的关系。

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BACKGROUND AND AIMS: The purpose of the current study was to examine the salivary flow rate and composition in relation to drug consumption and idiopathic oral sensorial complaints (OSC). OSC cover xerostomia, disturbed sense of taste, or burning mouth sensitivity with no established classical etiology (e.g., Sjogren's syndrome, or a response to radiotherapy). METHODS: A thorough sialometrical and sialochemical analysis was performed for all subjects who were healthy non-hospitalized individuals ranging in age from 18-89 years. Saliva samples were all collected in unstimulated conditions. RESULTS: The three most significant observations were: a) Elderly people have significantly reduced and altered salivary secretion. Whereas specific concentrations increased, the total values of most salivary components were found to be decreased in the elderly. b) Fifty percent of the elderly make OSC. c) OSC were made mainly by elderly individuals who use drugs. CONCLUSIONS: Reduction in salivary function and altered composition are age-related. However, when drugs are not involved, a compensatory capacity which avoids OSC apparently exists. In contrast, the effect of drugs on OSC is extensive. The finding that the total amount of salivary components and not only salivary flow rates are reduced in the elderly is of great clinical importance, since such a reduction is expected to be reflected in compromising various salivary functions.
机译：背景与目的：本研究的目的是检查唾液流速和成分与药物消耗和特发性口腔感觉不适（OSC）的关系。 OSC覆盖口干，口感紊乱或口角灼热，而没有明确的经典病因（例如，干燥综合征或对放射疗法的反应）。方法：对年龄在18-89岁之间的健康的非住院患者进行了全面的唾液酸化和唾液化学分析。唾液样品全部在未刺激的条件下收集。结果：三个最重要的观察结果是：a）老年人唾液分泌明显减少和改变。尽管特定浓度增加，但老年人中大多数唾液成分的总价值却降低了。 b）50％的老年人患有OSC。 c）OSC主要是由吸毒的老年人制作的。结论：唾液功能下降和组成改变与年龄有关。但是，当不涉及毒品时，显然存在避免OSC的补偿能力。相反，药物对OSC的影响广泛。降低老年人唾液成分的总量，不仅降低唾液流速的发现具有重要的临床意义，因为这种减少预计将反映在损害各种唾液功能中。

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