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首页> 外文期刊>Aging clinical and experimental research >Long-term trends in major cardiovascular risk factors in cohorts of aging men in the European cohorts of the Seven Countries Study.
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Long-term trends in major cardiovascular risk factors in cohorts of aging men in the European cohorts of the Seven Countries Study.

机译：欧洲七国研究队列中老年男性队列中主要心血管危险因素的长期趋势。

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BACKGROUND AND AIMS: Time trends in major cardiovascular risk factors are described in cohorts of middle-aged men followed for 35 years in 9 European cohorts of Finland, The Netherlands, Italy, Serbia and Greece. METHODS: Men aged 40 to 59 years at entry in the early 1960s were repeatedly re-examined 3 to 5 times over the last 35 years. Systolic blood pressure, serum cholesterol, body weight and body mass index were considered for analysis, including study of aging (35 years of follow-up) and of generation effects (10 years for men aged 50-59 in the period 1960-1970 and separately 10 years for men aged 75-84 years in the period 1985-1995). RESULTS: For the aging effect, average systolic blood pressure increased approximately 15 mmHg over 25 years maintaining a steady state thereafter, the largest increases being found in Serbia and Greece. Average serum cholesterol varied between approximately 4.5 in Serbia and 6.5 mmo/L in Finland in about 1960. Twenty-five years later, the average level was about 6 mmol/L in all five countries and decreased slightly thereafter. Average body weight and body mass index increased in all countries for 25 years and levelled off thereafter. For the generation effect, average systolic blood pressure decreased in all countries, with the exception of men aged 50-59 in Serbia and men aged 75-84 in The Netherlands. Average serum cholesterol uniformly increased in men aged 50-59 for the younger age-class and slightly decreased in men aged 75-84. Average body weight and body mass index increased systematically in all countries and in both age groups. CONCLUSIONS: Major changes were the great increases in average systolic blood pressure and serum cholesterol level in Serbia and in systolic blood pressure level in Greece between 1960 and 1985, and the large decrease in average serum cholesterol in Finland between 1970 and 1995. Average body weight and body mass index showed universal increases in both middle-aged and older men after 1960.
机译：背景与目的：在9个欧洲队列中的芬兰，荷兰，意大利，塞尔维亚和希腊的9个欧洲队列中，描述了主要心血管危险因素的时间趋势。方法：在1960年代初期，年龄40至59岁的男性在过去的35年中被重复检查了3至5次。考虑分析收缩压，血清胆固醇，体重和体重指数，包括研究衰老（35年的随访）和产生影响（1960-1970年期间50-59岁的男性10年，以及1985-1995年间年龄在75-84岁之间的男性分别为10年）。结果：由于衰老，平均收缩压在过去25年中增加了约15 mmHg，此后保持稳定，其中最大的升高发生在塞尔维亚和希腊。 1960年左右，塞尔维亚的平均血清胆固醇水平在4.5至6.5 mmo / L之间变化。二十五年后，所有五个国家的平均胆固醇水平均约为6 mmol / L，此后略有下降。在所有国家中，平均体重和体重指数在25年中一直在上升，此后趋于平稳。为了产生效果，所有国家的平均收缩压均下降，塞尔维亚的50-59岁男性和荷兰的75-84岁男性除外。对于年龄较小的年龄段，年龄在50-59岁的男性平均血清胆固醇均匀增加，而年龄在75-84岁的男性平均血清胆固醇略有下降。所有国家和两个年龄段的平均体重和体重指数都有系统地增加。结论：主要变化是塞尔维亚的平均收缩压和血清胆固醇水平大幅上升，希腊的收缩压水平在1960年至1985年之间大幅增加，芬兰的平均血清胆固醇水平在1970年至1995年之间大幅下降。平均体重体重指数显示1960年以后中年和老年人均普遍增加。

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