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首页> 外文期刊>Aging clinical and experimental research >Radiographic assessment of osteoarthritis: analysis of disease progression.
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Radiographic assessment of osteoarthritis: analysis of disease progression.

机译：骨关节炎的影像学评估：疾病进展分析。

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Osteoarthritis (OA) is one of the most prevalent and disabling chronic conditions affecting older adults, and is a significant public health problem among adults of working age. The knee is the most frequently involved joint site associated with disability in OA. Diagnosis of OA is primarily based on history and physical examination, but radiographic findings, including asymmetric joint space narrowing (JSN), subchondral sclerosis, osteophyte formation, subluxation, and distribution patterns of osteoarthritic changes are all helpful when diagnosis is uncertain. Structural morphological changes on X-rays are also considered the primary outcome variables for assessing the progression of OA. The development of new methods for prevention and treatment of OA requires improved understanding of the factors that influence its progression. The ability to assess progression quantitatively is a necessary first step in understanding factors that influence the disease process. Depending on the joint studied, several indices are currently used for assessing radiological progression of OA, including individual radiographic features (e.g., marginal osteophytes), composite indices (e.g., Kellgren and Lawrence scoring systems), and quantitative measures (e.g., joint space width measurement). Unfortunately, the review of studies evaluating the longitudinal rate of JSN indicates that the yearly change may be very small and of doubtful clinical significance. This emphasizes the need for further refinement in the definition of radiographic outcomes in prospective clinical trials. This review focuses on the available scoring methods used for the sites most frequently involved in OA (hand, knee, hip) and their various advantages and disadvantages.
机译：骨关节炎（OA）是影响老年人的最普遍且致残的慢性疾病之一，并且是工作年龄成年人中的重要公共卫生问题。膝关节是与OA残疾相关的最常见的关节部位。 OA的诊断主要基于病史和体格检查，但放射影像学检查结果（包括不对称关节间隙变窄（JSN），软骨下硬化，骨赘形成，半脱位和骨关节炎变化的分布模式）在诊断不确定时都是有帮助的。 X射线的结构形态变化也被认为是评估OA进展的主要结果变量。预防和治疗OA的新方法的发展需要对影响其进展的因素有更深入的了解。定量评估进展的能力是了解影响疾病过程的因素所必需的第一步。根据所研究的关节，当前使用几种指数来评估OA的放射学进展，包括个体的放射学特征（例如边缘骨赘），综合指数（例如Kellgren和Lawrence评分系统）和定量测量（例如关节间隙宽度）测量）。不幸的是，对评价JSN纵向速率的研究的回顾表明，每年的变化可能很小，并且对临床意义尚无定论。这强调在前瞻性临床试验中需要进一步完善放射线影像结果的定义。这篇综述着重于可用于OA最常涉及的部位（手，膝盖，臀部）的评分方法，以及它们的各种优缺点。

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