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Dual-Stimuli-Responsive Nanoassemblies as Tunable Releasing Carriers

机译：双刺激响应的纳米组件作为可调节的载体。

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摘要

Two end-decorated homopolyrners, methoxy polyethylene glycol-ferrocene (mPEG-Fc) and poly(N-isopropylacrylamide)-beta-cyclodextrin (PNIPAM-beta-CD), were further orthogonally self-assembled into stable micelles in aqueous solution by controlling the temperature of the solution via terminal host-guest interactions. Because of the H2O2 cleavable CD/Fc connection and thermoresponsive PNIPAM, an H2O2 and thermo dual-controlled drug release based on this system was also achieved. Interestingly, the cytotoxicity evaluation of mPEG-Fc/PNIPAM-beta-CD indicated good biocompatibility. Compared with free doxorubicin, the doxorubicin-loaded supramolecular micelles exhibited equal cellular proliferation inhibition toward A549 cells. This supramolecular complex is thus anticipated to serve as a promising new type of alternative drug-delivery system.
机译：通过控制溶剂的浓度，将两个末端修饰的均聚物，甲氧基聚乙二醇二茂铁（mPEG-Fc）和聚（N-异丙基丙烯酰胺）-β-环糊精（PNIPAM-β-CD）进一步正交自组装成稳定的胶束。通过终端主机与来宾的交互作用解决方案的温度。由于H2O2可裂解的CD / Fc连接和热响应性PNIPAM，因此也实现了基于该系统的H2O2和热双重控制药物释放。有趣的是，mPEG-Fc /PNIPAM-β-CD的细胞毒性评估表明良好的生物相容性。与游离阿霉素相比，负载阿霉素的超分子胶束对A549细胞具有相同的细胞增殖抑制作用。因此，这种超分子复合物有望用作一种有前途的新型替代药物递送系统。

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