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首页> 外文期刊>American Journal of Epidemiology >The influence of health and lifestyle characteristics on the relation of serum 25-hydroxyvitamin D with risk of colorectal and breast cancer in postmenopausal women
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The influence of health and lifestyle characteristics on the relation of serum 25-hydroxyvitamin D with risk of colorectal and breast cancer in postmenopausal women

机译：健康和生活方式特征对绝经后妇女血清25-羟基维生素D与结直肠癌和乳腺癌风险的关系的影响

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The authors' objective was to discern whether lifestyle or health-related factors were confounders, effect modifiers, or irrelevant with regard to understanding observational associations of serum 25-hydroxyvitamin D (25(OH)D) with colorectal and breast cancer. The authors conducted nested case-control studies of colorectal cancer (310 cases, 310 controls) and breast cancer (1,080 cases, 1,080 controls) in the Women's Health Initiative Calcium and Vitamin D Clinical Trial (1994-2005). Case-control matching factors included age, latitude, race/ethnicity, and blood collection date. Serum 25(OH)D was assayed in baseline fasting blood. Conditional logistic regression was used to estimate odds ratios for each cancer by serum 25(OH)D concentration, comparing the relative effects of successively adding body mass index, physical activity, and other health and lifestyle characteristics particular to each cancer. In models with matching factors only, low (vs. high) serum 25(OH)D was associated with a colorectal cancer odds ratio of 2.72 (95% confidence interval (CI): 1.55, 4.77) and a breast cancer odds ratio of 1.33 (95% CI: 1.02, 1.72). In multivariate-adjusted models for colorectal cancer, the association strengthened (OR = 4.45, 95% CI: 1.96, 10.10). However, in multivariate-adjusted breast cancer models, associations were no longer significant (OR = 1.06, 95% CI: 0.78, 1.43). Adjusting for health and lifestyle characteristics has differential effects depending on the cancer site; when modeling such relations, investigators should take these factors into account.
机译：作者的目的是辨别与生活方式或健康相关的因素是混杂因素，影响调节剂，还是与了解血清25-羟基维生素D（25（OH）D）与结直肠癌和乳腺癌的观察联系无关。作者在《妇女健康倡议钙与维生素D临床试验》（1994-2005年）中对大肠癌（310例，310例对照）和乳腺癌（1,080例，1,080例对照）进行了嵌套病例对照研究。病例对照匹配因素包括年龄，纬度，种族/民族和采血日期。在基线空腹血中测定血清25（OH）D。条件对数回归用于通过血清25（OH）D浓度估算每种癌症的比值比，比较相继增加体重指数，体力活动以及每种癌症特有的其他健康和生活方式特征的相对影响。在仅具有匹配因子的模型中，低（相对于高）血清25（OH）D与结直肠癌的优势比为2.72（95％置信区间（CI）：1.55，4.77）和乳腺癌的优势比为1.33相关（95％CI：1.02，1.72）。在针对大肠癌的多变量调整模型中，关联性增强（OR = 4.45，95％CI：1.96，10.10）。但是，在经过多变量调整的乳腺癌模型中，关联不再显着（OR = 1.06，95％CI：0.78，1.43）。根据癌症部位的不同，调整健康和生活方式特征会产生不同的影响。在建立这种关系的模型时，研究人员应考虑这些因素。

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