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首页> 外文期刊>American Journal of Epidemiology >Early life growth and hemostatic factors: the Barry Caerphilly Growth study.
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Early life growth and hemostatic factors: the Barry Caerphilly Growth study.

机译：早期生命的成长和止血因素：Barry Caerphilly成长研究。

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摘要

Associations between early life growth trajectories and a range of adult (aged approximately 25 years) hemostatic factors were assessed in the Barry Caerphilly Growth study (N = 517) in South Wales, 1974-1999. Associations of birth weight, birth length, and weight and height velocities during three periods ("immediate": 0-<5 months, "infant": 5 months-<1 year 9 months, and "childhood": 1 year 9 months-5 years) with adult levels of hemostatic factors were assessed. Birth weight was inversely associated with fibrinogen (beta per 1-unit change in z score = -0.08, 95% confidence interval (CI): -0.15, -0.02). Immediate weight velocity was inversely associated with factor VII (beta = -1.88, 95% CI: -3.84, 0.09), factor VIII (beta = -2.58, 95% CI: -4.07, -0.45), and von Willebrand factor antigen (beta = -4.07, 95% CI: -7.25, -0.89). Birth length was inversely associated with fibrinogen (beta = -0.07, 95% CI: -0.14, -0.01). Evidence was weaker for an inverse association of immediate height velocity with factorVIII (beta = -2.16, 95% CI: -4.62, 0.29) and von Willebrand factor antigen (beta = -2.85, 95% CI: -6.52, 0.81). Childhood height velocity was positively associated with D-dimer (ratio of geometric means = 1.11, 95% CI: 1.01, 1.23). Results support the view that the immediate postnatal period may be particularly important, possibly through impaired liver development and/or infection in early life, in determining cardiovascular disease risk.
机译：1974-1999年在南威尔士进行的Barry Caerphilly Growth研究（N = 517）中评估了早期生命增长轨迹与一系列成人（约25岁）止血因子之间的关联。三个时期的出生体重，出生长度以及体重和身高速度的关联（“立即”：0- <5个月，“婴儿”：5个月-<1年9个月，“童年”：1年9个月- 5岁）与成人止血因子水平进行了评估。出生体重与血纤蛋白原呈负相关（z得分每变化1个单位，β= -0.08，95％置信区间（CI）：-0.15，-0.02）。即时体重速度与因子VII（β= -1.88，95％CI：-3.84，0.09），因子VIII（β= -2.58，95％CI：-4.07，-0.45）和von Willebrand因子抗原（ β= -4.07，95％CI：-7.25，-0.89）。出生时间与血纤蛋白原成反比（β= -0.07，95％CI：-0.14，-0.01）。近期身高速度与因子VIII（β= -2.16，95％CI：-4.62，0.29）和von Willebrand因子抗原（β= -2.85，95％CI：-6.52，0.81）负相关的证据较弱。儿童期身高速度与D-二聚体呈正相关（几何平均值之比= 1.11，95％CI：1.01，1.23）。结果支持这样的观点，即在确定心血管疾病风险时，可能是由于产后早期肝脏发育受损和/或感染，可能是产后立即特别重要。

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