The role of lipoprotein-associated phospholipase a as a marker and potential therapeutic target in atherosclerosis.

Stewart RA; White HD

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The role of lipoprotein-associated phospholipase a as a marker and potential therapeutic target in atherosclerosis.

机译：脂蛋白相关磷脂酶a在动脉粥样硬化中作为标志物和潜在治疗靶标的作用。

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Lipoprotein-associated phospholipase A (Lp-PLA) is an enzyme that generates inflammatory mediators within atherosclerotic plaques. In epidemiologic studies there is an association between higher plasma Lp-PLA activity and myocardial infarction, stroke and cardiovascular mortality. In animal models, darapladib, a specific inhibitor of Lp-PLA, decreases the size of the atheroma necrotic core and plaques with thin fibrous caps. Early clinical trials suggest darapladib effectively and safely inhibits Lp-PLA activity both in plasma and in carotid atheroma. Two large phase III clinical trials that are currently in progress will determine whether darapladib will reduce the risk of myocardial infarction, stroke, and cardiovascular death by stabilizing atherosclerotic plaques.

机译：脂蛋白相关的磷脂酶A（Lp-PLA）是一种在动脉粥样硬化斑块内产生炎症介质的酶。在流行病学研究中，血浆Lp-PLA活性较高与心肌梗塞，中风和心血管疾病死亡率之间存在关联。在动物模型中，darapladib是Lp-PLA的一种特异抑制剂，可减小动脉粥样硬化坏死核心和具有纤细纤维帽的斑块的大小。早期的临床试验表明，darapladib有效和安全地抑制血浆和颈动脉粥样硬化中的Lp-PLA活性。目前正在进行的两项大型III期临床试验将确定达拉帕地平是否通过稳定动脉粥样硬化斑块来降低心肌梗塞，中风和心血管死亡的风险。

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《Current atherosclerosis reports.》 |2011年第2期|共6页
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Stewart RA; White HD;
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中图分类心脏、血管（循环系）疾病;
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1. The role of lipoprotein-associated phospholipase a as a marker and potential therapeutic target in atherosclerosis. [J] . Stewart RA, White HD Current atherosclerosis reports. . 2011,第2期

机译：脂蛋白相关磷脂酶a在动脉粥样硬化中作为标志物和潜在治疗靶标的作用。
2. Lipoprotein-associated phospholipase A_2:a novel marker of cardiovascular risk and potential therapeutic target [J] . Colin Macphee, G Martin Benson, Yi Shi, Expert opinion on investigational drugs . 2005,第6期

机译：脂蛋白相关的磷脂酶A_2：心血管疾病风险和潜在治疗目标的新标记
3. Role of lipoprotein-associated phospholipase A2 in atherosclerosis and its potential as a therapeutic target. [J] . Macphee CH, Nelson J, Zalewski A Current opinion in pharmacology . 2006,第2期

机译：脂蛋白相关磷脂酶A2在动脉粥样硬化中的作用及其作为治疗靶标的潜力。
4. Telomerase is Significant as an Early Diagnostic Marker and Therapeutic Target [C] . Lian Duan, Nan Wang, Xinghua Liao, International conference on applied biotechnology . 2014

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6. Lipoprotein-associated phospholipase A2 (Lp-PLA2) as a therapeutic target to prevent retinal vasopermeability during diabetes [O] . Paul Canning, Bridget-Ann Kenny, Vivien Prise, 2016

机译：脂蛋白相关的磷脂酶A2（Lp-PLA2）作为预防糖尿病期间视网膜血管通透性的治疗靶标
7. Lipoprotein-associated phospholipase A2 (Lp-PLA2) as a marker of atherosclerotic activity and a potential therapeutic target [O] . Helena Vaverková, David Karásek 2011

机译：脂蛋白相关的磷脂酶A2（LP-PLA2）作为动脉粥样硬化活性和潜在治疗靶标的标志物

The role of lipoprotein-associated phospholipase a as a marker and potential therapeutic target in atherosclerosis.

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