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首页> 外文期刊>薬理と治療 >Effects of Intake of Psyllium Husk on Blood Pressure in Subjects with High-normal Blood Pressure —Randomized, Double-blind, Placebo-controlled Parallel-group Study—
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Effects of Intake of Psyllium Husk on Blood Pressure in Subjects with High-normal Blood Pressure —Randomized, Double-blind, Placebo-controlled Parallel-group Study—

机译：腹腔壳对高正常血压受试者血压的影响 - 萌芽，双盲，安慰剂控制平行群体研究 -

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Objectives This study aimed to investigate the effects of psyllium husk intake on blood pressure in high-normal blood pressure subjects. Methods A randomized, double-blind, placebo-controlled, parallel-group study was conducted in 72 high-normal blood pressure subjects. The subjects were randomly assigned to either the psyllium group (n = 36) or the placebo-controlled group (n = 36). The subjects consumed the study product before each of the three daily meals for 12 weeks. The psyllium group consumed test food containing 3.6 g of dietary fiber derived from psyllium husk at a time, and the placebo group consumed control food without dietary fiber derived from psyllium husk. The changes in the blood pressure levels of the two groups were compared. Results Seventy subjects completed the study. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) of the two groups were not significantly different. However, subgroup analysis of subjects whose estimated daily salt intake during the study were above the mean of subjects revealed that the change from baseline to Week 12 in SBP was significantly greater in psylfium group (P<0.05). Conclusion These results suggest that continuous intake of dietaiy fiber derived from psyllium husk decreases SBP in high-normal blood pressure subjects with a high salt intake. (UMIN000035223)
机译：目的本研究旨在探讨乳头壳摄入对高正常血压受试者血压的影响。方法采用随机，双盲，安慰剂，并联研究，在72个高正常血压对象中进行。将受试者随机分配给母碱基（n = 36）或安慰剂对照组（n = 36）。受试者在每日每日膳食中的每一餐之前消耗研究产品12周。腹股沟群消耗含有3.6g膳食纤维的试验食物，一次衍生自牛头腹乳纤维，安慰剂组消耗衍生自牛肝纤维的膳食纤维的控制食物。比较了两组血压水平的变化。结果70个科目完成了这项研究。两组的收缩压（SBP）和舒张压（DBP）没有显着差异。然而，对研究期间估计日常盐摄入量的受试者的亚组分析高于受试者的平均值，表明，在PsyleL组中，SBP中基线的变化在SBP中显着更大（P <0.05）。结论这些结果表明，衍生自腹腔壳的饮食纤维的连续摄入量降低了高正常血压受试者的高盐摄入量。 （UMIN000035223）

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