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首页> 外文期刊>American Journal of Epidemiology >Temporal Relationship Between Elevated Blood Pressure and Arterial Stiffening Among Middle-Aged Black and White Adults
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Temporal Relationship Between Elevated Blood Pressure and Arterial Stiffening Among Middle-Aged Black and White Adults

机译：中老年人和成年人的血压升高与动脉硬化之间的时间关系

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摘要

This study assessed the temporal relationship between elevated blood pressure (BP) and arterial stiffness in a biracial (black-white) cohort of middle-aged adults aged 32-51 years from the semirural community of Bogalusa, Louisiana. Measurements of aortic-femoral pulse wave velocity (afPWV; n = 446) and large-and small-arterial compliance (n = 381) were obtained at 2 time points between 2000 and 2010, with an average follow-up period of 7 years. A cross-lagged path analysis model was used to examine the temporal relationship of elevated BP to arterial stiffness and elasticity. The cross-lagged path coefficients did not differ significantly between blacks and whites. The path coefficient (rho(2)) from baseline BP to follow-up afPWV was significantly greater than the path coefficient (rho(1)) from baseline afPWV to follow-up BP (rho(2) = 0.20 vs rho(1) = 0.07 (P = 0.048) for systolic BP; rho(2) = 0.19 vs rho(1) = 0.05 (P = 0.034) for diastolic BP). The results for this 1-directional path from baseline BP to follow-up afPWV were confirmed, although marginally significant, by using large-and small-artery elasticity measurements. These findings provide strong evidence that elevated BP precedes large-artery stiffening in middle-aged adults. Unlike the case in older adults, the large-arterial wall is not stiff enough in youth to alter BP levels during young adulthood.
机译：这项研究评估了路易斯安那州Bogalusa的半农村社区的32-51岁中年人的混血儿（黑白）队列中高血压（BP）与动脉僵硬之间的时间关系。在2000年至2010年的两个时间点测量了主动脉-股动脉脉搏波速度（afPWV; n = 446）和大，小动脉顺应性（n = 381），平均随访时间为7年。交叉滞后路径分析模型用于检查血压升高与动脉僵硬和弹性的时间关系。黑人和白人之间的交叉滞后路径系数没有显着差异。从基线BP到后续afPWV的路径系数（rho（2））显着大于从基线afPWV到后续BP的路径系数（rho（1））（rho（2）= 0.20 vs rho（1）对于收缩压= 0.07（P = 0.048）;对于舒张压而言，rho（2）= 0.19 vs rho（1）= 0.05（P = 0.034））。通过使用大动脉和小动脉的弹性测量，从基线BP到随访afPWV的这种1向路径的结果得到了证实，尽管微不足道。这些发现提供了有力的证据，表明中年成年人血压升高先于大动脉硬化。与老年人不同，大动脉壁在年轻人中不足以改变血压水平。

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