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首页> 外文期刊>American journal of transplantation: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons >Severing Corneal Nerves in One Eye Induces Sympathetic Loss of Immune Privilege and Promotes Rejection of Future Corneal Allografts Placed in Either Eye
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Severing Corneal Nerves in One Eye Induces Sympathetic Loss of Immune Privilege and Promotes Rejection of Future Corneal Allografts Placed in Either Eye

机译：一只眼睛断绝角膜神经会导致免疫特权的同情丧失，并促进排斥两只眼睛中放置的未来角膜同种异体移植物

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Less than 10% of corneal allografts undergo rejection even though HLA matching is not performed. However, second corneal transplants experience a threefold increase in rejection, which is not due to prior sensitization to histocompatibility antigens shared by the first and second transplants since corneal grafts are selected at random without histocompatibility matching. Using a mouse model of penetrating keratoplasty, we found that 50% of the initial corneal transplants survived, yet 100% of the subsequent corneal allografts (unrelated to the first graft) placed in the opposite eye underwent rejection. The severing of corneal nerves that occurs during surgery induced substance P (SP) secretion in both eyes, which disabled T regulatory cells that are required for allograft survival. Administration of an SP antagonist restored immune privilege and promoted graft survival. Thus, corneal surgery produces a sympathetic response that permanently abolishes immune privilege of subsequent corneal allografts, even those placed in the opposite eye and expressing a completely different array of foreign histocompatibility antigens from the first corneal graft.
机译：即使不进行HLA匹配，也只有不到10％的角膜同种异体移植发生排斥反应。但是，第二次角膜移植的排斥反应增加了三倍，这不是由于对第一和第二次移植所共有的组织相容性抗原的事先敏化，因为随机选择了角膜移植物而没有组织相容性匹配。使用穿透性角膜移植的小鼠模型，我们发现最初的角膜移植物中有50％存活，而另一只眼中放置的随后的角膜同种异体移植物（与第一个移植物无关）却遭到排斥。在手术过程中发生的角膜神经切断导致两只眼睛的物质P（SP）分泌，这使异体移植存活所需的T调节细胞失活。 SP拮抗剂的施用恢复了免疫特权并促进了移植物存活。因此，角膜手术产生的交感反应永久性地消除了随后的角膜同种异体移植物的免疫特权，即使是那些放在另一只眼中并表达出与第一个角膜移植物完全不同的外源组织相容性抗原的移植物。

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