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首页> 外文期刊>American Journal of Veterinary Research >Humoral immunity and injection-site reactions in cattle vaccinated with a multivalent clostridial vaccine administered via subcutaneous injection or via transdermal needle-free injection
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Humoral immunity and injection-site reactions in cattle vaccinated with a multivalent clostridial vaccine administered via subcutaneous injection or via transdermal needle-free injection

机译：经皮下注射或无针皮下注射多价梭菌疫苗接种的牛的体液免疫和注射部位反应

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Objective-To evaluate injection-site reactions and serum antibody titers in cattle vaccinated with a clostridial vaccine administered SC or via needle-free transdermal injection.Animals-Sixteen 11- to 12-month-old Herefords.Procedures-Cattle in 2 groups were vaccinated on days 0 and 28 with a commercially available multivalent clostridial vaccine administered SC or transdermally. Injection sites and serum antibody titers were evaluated at several time points after vaccination. Serum antibody titers against Clostridium perfringens beta toxin, Clostridium novyi alpha toxin, and Clostridium septicum alpha toxin were determined with an ELISA; Clostridium sordellii lethal toxin titers were determined with a toxin neutralization assay.Results-Firm injection site swellings developed in cattle vaccinated via either route; however, at several observation times, swellings were significantly smaller in cattle vaccinated transdermally. Serum titers against C perfringens beta toxin and C septicum alpha toxin did not differ significantly between groups after vaccination; serum titers against C novyi alpha toxin were not significantly different between groups, except on days 10 and 56, when they were significantly higher in cattle vaccinated SC. Titers against C sordellii lethal toxin were significantly higher in cattle vaccinated SC on several days after vaccination, but titers were not significantly different after day 49.Conclusions and Clinical Relevance-Transdermal vaccination of cattle resulted in serum antibody titers that were similar to those induced via SC vaccination and caused injection-site reactions that were significantly smaller. Transdermal vaccination may be an effective technique for vaccinating cattle against clostridial diseases while minimizing local reactions that often develop after clostridial vaccination. (Am J Vet Res 2011;72:1124-1129)
机译：目的-评价接种梭菌疫苗或无针透皮注射疫苗的牛的注射部位反应和血清抗体滴度。动物-16只11至12个月大的赫里福德犬-两组均进行牛程序接种。在第0天和第28天使用SC或经皮给药的市售多价梭菌疫苗接种。接种后几个时间点评估注射部位和血清抗体滴度。用ELISA测定抗产气荚膜梭菌β毒素，新孢梭菌α毒素和败血梭菌α毒素的血清抗体滴度;用毒素中和测定法测定了梭菌梭状芽孢杆菌的致死毒素滴度。然而，在几个观察时间，经皮接种牛的肿胀明显较小。接种疫苗后各组之间针对产气荚膜梭菌β毒素和败血性丙酸杆菌毒素的血清效价没有显着差异。除在第10天和第56天时（在牛接种SC的牛中显着更高）外，各组抗诺维尼C毒素的血清滴度没有显着差异。接种疫苗后的几天，接种牛的SC中抵抗索氏梭菌致命毒素的滴度显着较高，但在第49天后滴度没有显着差异。 SC疫苗接种和注射部位反应明显减少。透皮疫苗接种可能是一种有效的技术，可为牛接种抗梭菌病的疫苗，同时最大程度地减少在梭菌疫苗接种后经常发生的局部反应。 （Am J Vet Res 2011; 72：1124-1129）

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