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首页> 外文期刊>American Journal of Veterinary Research >Comparison of pathological changes and viral antigen distribution in tissues of calves with and without preexisting bovine viral diarrhea virus infection following challenge with bovine herpesvirus-1
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Comparison of pathological changes and viral antigen distribution in tissues of calves with and without preexisting bovine viral diarrhea virus infection following challenge with bovine herpesvirus-1

机译：牛疱疹病毒1攻击后有和没有牛病毒性腹泻病毒感染的犊牛组织中病理变化和病毒抗原分布的比较

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Objective-To compare pathological changes and viral antigen distribution in tissues of calves with and without preexisting subclinical bovine viral diarrhea virus (BVDV) infection following challenge with 'bovine herpesvirus-1 (BHV-1). Animals-24 Friesian calves. Procedures-12 calves were inoculated intranasally with noncytopathic BVDV-la; 12 days later, 10 of these calves were challenged intranasally with BHV-1 subtype 1. Two calves were euthanized before and 1, 2, 4, 7 or 14 days after BHV-1 inoculation. Another 10 calves were inoculated intranasally with BHV-1 only and euthanized 1, 2, 4, 7, or 14 days later. Two calves were inoculated intranasally with virus-free tissue culture fluid and euthanized as negative controls. Pathological changes and viral antigen distribution in various tissue samples from calves with and without BVDV infection (all of which had been experimentally inoculated with BHV-1) were compared. Results-Following BHV-1 challenge, calves with preexisting subclinical BVDV infection had earlier development of more severe inflammatory processes and, consequently, more severe tissue lesions (limited to lymphoid tissues and respiratory and digestive tracts) and greater dissemination of BHV-1, compared with calves without preexisting BVDV infection. Moreover, coinfected calves had an intense lymphoid depletion in the Peyer patches of the ileum as well as the persistence of BVDV in target organs and the reappearance of digestive tract changes during disease progression. Conclusions and Clinical Relevance-In calves, preexisting infection with BVDV facilitated the establishment of BHV-1 infection, just as the presence of BHV-1 favors BVDV persistence, thereby synergistically potentiating effects of both viruses and increasing the severity of the resultant clinical signs. (Am J Vet Res 2013;74:598-610)
机译：目的-比较在感染和不感染亚临床牛病毒性腹泻病毒（BVDV）的小牛组织中，用'牛疱疹病毒1（BHV-1）攻击后的病理变化和病毒抗原分布。动物24弗里斯兰牛犊。步骤12只小牛经鼻内接种无细胞病性BVDV-1a; 12天后，将这些小牛中的10只用BHV-1亚型1鼻内攻击。在接种BHV-1之前和之后1、2、4、7或14天对两只小牛实施安乐死。仅鼻内接种另外10头小牛，并在1、2、4、7或14天后安乐死。将两只小牛用无病毒的组织培养液鼻内接种并安乐死作为阴性对照。比较了有和没有BVDV感染（均已通过BHV-1实验接种）的犊牛各种组织样品中的病理变化和病毒抗原分布。结果：在进行BHV-1攻击后，与先前存在亚临床BVDV感染的犊牛相比，较早出现了更严重的炎症过程，因此，更严重的组织损伤（仅限于淋巴组织以及呼吸道和消化道）和BHV-1的传播更加广泛犊牛没有预先感染BVDV。此外，合并感染的小牛在回肠的Peyer斑中有强烈的淋巴样消耗，并且BVDV在靶器官中持续存在，并在疾病进展期间重新出现了消化道变化。结论和临床相关性-在小牛中，先前存在的BVDV感染促进了BHV-1感染的建立，就像BHV-1的存在有利于BVDV持久性一样，从而协同增强了这两种病毒的作用并增加了所产生的临床症状的严重性。 （Am J Vet Res 2013; 74：598-610）

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