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首页> 外文期刊>American Journal of Veterinary Research >In vivo effects of intra-articular injection of gelatin hydrogen microspheres containing basic fibroblast growth factor on experimentally induced defects in third metacarpal bones of horses
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In vivo effects of intra-articular injection of gelatin hydrogen microspheres containing basic fibroblast growth factor on experimentally induced defects in third metacarpal bones of horses

机译：关节内注射含碱性成纤维细胞生长因子的明胶氢微球对马第三掌骨实验性诱发的缺损的体内作用

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Objective-To evaluate the effect of intra-articular injection of gelatin hydrogel microspheres containing basic fibroblast growth factor (bFGF) on experimentally induced defects in third metacarpal bones (MC3s) of horses, in vivo. Animals-6 healthy adult Thoroughbreds. Procedures-Horses were anesthetized, and a hole (diameter, 4.5 mm) was drilled into the medial condyle of both MC3s of each horse. One milliliter (100 mug) of a solution of gelatin hydrogel microspheres (2 mg) containing bFGF was injected into the joint capsule of the right metacarpophalangeal joint of each horse (bFGF joint). One milliliter of saline (0.9% NaCl) solution was injected into the left metacarpophalangeal joint (control joint). Radiography was performed 1 day and 4, 8, 12, and 16 weeks after surgery to evaluate bone defect refilling. Sixteen weeks after surgery, multidetector-row computed tomography (MDRCT) was performed to determine the degree of refilling at the bone defect site. Results-Radiography revealed healing of bone defects at 4 to 12 weeks after surgery in bFGF joints and at 8 to 16 weeks after surgery in control joints. In addition, MDRCT revealed a higher degree of healing in bFGF versus control joints. Mean +/- SD MDRCT score for bFGF joints (411.7 +/- 135.6 Hounsfield units) was significantly higher than that for control joints (240.8 +/- 133.1 Hounsfield units). Conclusions and Clinical Relevance-Treatment of horses with gelatin hydrogel microspheres that contained bFGF enhanced bone regeneration and healing of experimentally induced defects. This treatment strategy may be useful for treating horses with fractures.
机译：目的-关节内注射含碱性成纤维细胞生长因子（bFGF）的明胶水凝胶微球对实验性诱导的马第三掌骨（MC3s）缺陷的影响。动物-6个健康的成年纯种马。步骤-麻醉马，并在每匹马的两个MC3的内侧con上钻一个洞（直径4.5毫米）。将一毫升（100杯）含bFGF的明胶水凝胶微球（2 mg）溶液注入每匹马的右掌指关节（bFGF关节）的关节囊中。将一毫升盐水（0.9％NaCl）溶液注入左掌指关节（对照关节）。术后1天和4、8、12和16周进行X线检查，以评估骨缺损的补充情况。手术后十六周，进行了多排行计算机断层扫描（MDRCT），以确定骨缺损部位的充盈程度。结果影像学检查显示，bFGF关节在手术后4至12周和对照关节在手术后8至16周均能治愈骨缺损。此外，MDRCT显示与对照关节相比，bFGF的愈合程度更高。 bFGF关节的平均+/- SD MDRCT得分（411.7 +/- 135.6霍恩斯单位）显着高于对照关节的平均+/- SD MDRCT得分（240.8 +/- 133.1霍恩斯单位）。结论与临床相关性用含有bFGF的明胶水凝胶微球治疗马匹可增强骨骼再生和实验性缺陷的愈合。这种治疗策略可能对治疗骨折的马有用。

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