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首页> 外文期刊>American Zoologist >The taurine efflux portal used to regulate cell volume in response to hypoosmotic stress seems to be similar in many cell types: Lessons to be learned from molluscan red blood cells
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The taurine efflux portal used to regulate cell volume in response to hypoosmotic stress seems to be similar in many cell types: Lessons to be learned from molluscan red blood cells

机译：在许多细胞类型中，用来调节低渗压力的牛磺酸外流门户似乎很相似：从软体动物红血球中吸取的教训

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摘要

The control of cell volume in all cell types is accomplished by the regulation of two general categories of osmolytes: inorganic ions, most commonly K+ and Cl-, and small molecular weight organic compounds, usually certain amino acids and certain quaternary ammonium compounds. The difference in who regulates what does not depend phylogeny, but instead upon the type of osmotic environment that a cell expects (in an evolutionary sense) to encounter. Cells that exist in extracellular osmotic concentrations up to 300-400 mosmol/kg (mosm) rely primarily on inorganic osmolytes for volume control, while cells that exist at greater osmotic concentrations rely more on organic osmolytes for volume control. Usually, strange or unique volume regulatory mechanisms are found in cells that exist in particularly demanding osmotic conditions. In order to provide further support the foregoing generalizations, the following paper will focus on comparisons between the hypoosmotically induced mechanism of taurine efflux regulation by red blood cells of the bivalve, Noetia ponderosa, probably the best understood "invertebrate" cell type in this regard, and taurine efflux from a variety of "vertebrate" cells.
机译：在所有细胞类型中，细胞体积的控制可通过调节两大类渗透压来实现：无机离子（最常见的是K +和Cl-）和小分子量有机化合物（通常为某些氨基酸和某些季铵化合物）。谁调节什么的差异并不取决于系统发育，而是取决于细胞期望（在进化意义上）遇到的渗透环境的类型。存在于细胞外渗透浓度最高为300-400 mosmol / kg（mosm）的细胞主要依赖于无机渗透物来控制体积，而存在于更高渗透浓度的细胞则更多地依赖有机渗透物来控制体积。通常，在存在特别苛刻的渗透条件的细胞中发现奇怪或独特的体积调节机制。为了进一步为上述概括提供支持，以下论文将重点比较双壳类红血球（Noetia tankerosa）的红细胞在低渗诱导的牛磺酸外流调节机制之间的比较，这可能是对此最了解的“无脊椎动物”细胞类型，牛磺酸从各种“脊椎动物”细胞中流出。

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