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The neuroanatomy of nitric oxide-cyclic GMP signaling in the locust: Functional implications for sensory systems

机译:刺槐中一氧化氮-环GMP信号传导的神经解剖:感觉系统的功能含义。

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Recent studies have investigated the source and target neurons for the diffusible neuronal messenger molecule nitric oxide (NO) in the nervous system of the locust. Here we compare the neuroarchitecture of NO signaling between different sensory systems. The available neuroanatomical data implicate NO in sensory processing for modalities as diverse as mechanoreception, vision, olfaction, gustation and hearing. All respective first-order sensory neuropils are innervated by NOS-containing inlerneurons. The corresponding sensory receptor neurons lack NOS but seem to express soluble guanylyl cyclase (sGC), the main receptor molecule for NO in the nervous system. The axonal projections of sensory neurons must therefore be considered the primary target of NO in these sensory neuropils. An exception is the antennal olfactory system where sGC is apparently expressed in interneurons, in partial colocalization with NOS.
机译:最近的研究已经研究了蝗虫神经系统中弥散性神经元信使分子一氧化氮(NO)的来源和目标神经元。在这里,我们比较不同感觉系统之间的NO信号传导的神经体系结构。现有的神经解剖学数据暗示NO涉及各种形式的感觉处理,如机械感受,视觉,嗅觉,味觉和听觉。所有相应的一阶感觉神经纤维均受含NOS的不敏感神经支配。相应的感觉受体神经元缺乏NOS,但似乎表达可溶性鸟苷基环化酶(sGC),这是神经系统中NO的主要受体分子。因此,必须将感觉神经元的轴突投影视为这些感觉神经桩中NO的主要靶标。一个例外是触角嗅觉系统,其中sGC明显在中间神经元中表达,与NOS部分共定位。

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