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Gaseous transmission across time and species

机译:跨时间和跨物种的气体传输

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This paper reviews comparative and evolutionary aspects of nitric oxide (NO) signaling in major systematic groups such as prokaryotes, plants, fungi and invertebrate animals. It appears that NO-mediated signaling can be as old as cellular organization itself. Both non-enzymatic and enzymatic (in addition to NOS) synthetic pathways can contribute to NO formation in living systems. The evolutionary roots of this means of gaseous signaling can be traced back to tile role of NO in non-immune defensive mechanisms and the role of NO in control of gene expression, chemical ecology and, perhaps, symbiotic interactions in the ancient prokaryotic world. These functions of NO can be preserved in practically all modern taxons and be widely expressed in the nervous system. However, it is hypothesized that neuronal NO signaling is a relatively new evolutionary invention and it is likely to have happened several times during animal evolution. Although a comparative analysis of neuronal NO signaling is still in its early stages, the hypothesis is proposed that in many invertebrate lineages one of tile primary neuronal functions of NO was regulation of feeding patterns, chemosensory processing and neurodevelopment.
机译:本文概述了主要系统群体(如原核生物,植物,真菌和无脊椎动物)中一氧化氮(NO)信号的比较和进化方面。似乎NO介导的信号传导可能与细胞组织本身一样古老。非酶促途径和酶促途径(除了NOS)都可以促进生物系统中NO的形成。这种气体信号传导方式的进化根源可以追溯到NO在非免疫防御机制中的作用以及NO在控制基因表达,化学生态学以及也许在古代原核世界中的共生相互作用中的作用。这些NO的功能几乎可以保留在所有现代分类单元中,并在神经系统中广泛表达。然而,假设神经元NO信号传导是一个相对较新的进化发明,它可能在动物进化过程中发生了几次。尽管对神经元NO信号的比较分析仍处于早期阶段,但提出的假设是,在许多无脊椎动物谱系中,NO的主要神经元功能之一是调节进食方式,化学感应过程和神经发育。

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