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Diurnal variation of upper and lower tear menisci.

机译:上下眼泪半月板的日变化。

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摘要

PURPOSE: To determine diurnal variation of tear menisci around upper and lower eyelids in normal subjects. DESIGN: Prospective laboratory investigation. METHODS: Twenty young healthy Chinese subjects (10 women and 10 men; mean age, 21.3 years; range, 20 to 26 years) with no history of contact lens wear or previously diagnosed dry eye were recruited. A custom-built, real-time anterior segment optical coherence tomography (OCT) instrument was used simultaneously to image the upper and lower tear menisci. Repeated measurements immediately after blinking were conducted on both eyes during a 24-hour period, including immediately before and after sleeping. Dimensional information of the tear menisci were obtained from the OCT images using custom software. RESULTS: There were no significant differences between right and left menisci, nor were there any differences between females and males in the lower tear meniscus (P > .05, repeated-measurement analysis of variance [ANOVA]). Although the lower tear meniscusvariables were correlated strongly with upper meniscus variables, the lower meniscus was significantly greater than the upper one. Significant diurnal variations (P < .05, repeated-measurement ANOVA) of all measured variables were observed during the study period. Tear menisci were significantly increased at eye opening after overnight sleep compared with the baseline before sleep at 10 pm (P < .001, post hoc tests). They remained elevated up to 10 minutes after eye opening (P < .001, post hoc tests). CONCLUSIONS: Real-time OCT can provide useful information regarding the dynamics of the tear system. Diurnal variation of the upper and lower tear menisci occur.
机译:目的:确定正常受试者上下眼睑周围撕裂半月板的昼夜变化。设计:前瞻性实验室调查。方法:招募了二十名年轻健康的中国受试者(10名女性和10名男性;平均年龄21.3岁;范围20至26岁),没有戴隐形眼镜的病史或先前被诊断出患有干眼症。同时使用定制的实时前段光学相干断层扫描(OCT)仪器对上,下泪液半月板进行成像。眨眼后立即在24小时内对两只眼睛进行重复测量,包括在睡觉前后。使用定制软件从OCT图像中获取泪液半月板的尺寸信息。结果:下半月板的右半月板和左半月板之间无显着差异,男女之间也无任何差异(P> .05,方差重复测量分析[ANOVA])。尽管下半月板撕裂变量与上半月板变量密切相关,但下半月板明显大于上半月板。在研究期间,观察到所有测量变量的显着昼夜变化(P <.05,重复测量方差分析)。与晚上10点睡觉前的基线相比,过夜睡觉后眼睁开时的泪液半月板显着增加(P <.001,事后检验)。睁眼后10分钟内它们仍保持升高状态(P <.001,事后检验)。结论:实时OCT可以提供有关泪液系统动力学的有用信息。上,下眼泪半月板的日变化。

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